Brain metastasis from medullary thyroid carcinoma. (29th December 2010)

• Record Type: Journal Article
• Authors: Börcek, P; Asa, S L; Gentili, F; Ezzat, S; Kiehl, T-R
• Is Part Of: BMJ case reports. Volume 2010
• Publication Date: 2010-12-29
• Subjects: Medicine -- Case studies -- Periodicals; 610.5
• DOI: 10.1136/bcr.09.2010.3301
• Languages: English
• ISSNs: 1757-790X

Abstract

Abstract : The brain is an exceedingly rare site of metastasis in medullary thyroid carcinoma (MTC). A 50-year-old female who had a history of micro-MTC 11 years prior developed a cerebellar metastasis which was incidentally discovered. Imaging revealed a right cerebellar hemispheric mass with contrast enhancement on CT scans. Histopathologic exam demonstrated a metastatic tumour composed of nodules and sheets of large tumour cells with abundant cytoplasm. Immunohistochemistry confirmed the origin from a MTC. This case report highlights the unique features of an unusual metastatic brain tumour, which followed an indolent course for a long time despite multiple distant metastases.