Weight gain after oophorectomy among women with a BRCA1 or BRCA2 mutation. (July 2015)

• Record Type: Journal Article
• Authors: Kotsopoulos, Joanne; Lubinski, Jan; Neuhausen, Susan L; Gronwald, Jacek; Lynch, Henry T; Huzarski, Tomasz; Demsky, Rochelle; Foulkes, William D; Senter, Leigha; Friedman, Susan; Ainsworth, Peter; Sun, Ping; Narod, Steven A
• Is Part Of: Women's health. Volume 11:Number 4(2015)
• Page Start: 453
• Page End: 459
• Publication Date: 2015-07
• Subjects: BRCA1 -- BRCA2 -- oophorectomy -- weight gain; Gynecology -- Periodicals; Obstetrics -- Periodicals; Women -- Health and hygiene -- Periodicals; 618.05
• DOI: 10.2217/whe.15.4
• Languages: English
• ISSNs: 1745-5057

Abstract

Aim: To measure weight gain among unaffected women with a BRCA1 or BRCA2 mutation after undergoing an oophorectomy.Patients & methods: We compared the bodyweight of women with (n = 405) and without an oophorectomy (n = 741) at baseline as well as the rate of weight change prior to and following surgery among 1454 BRCA mutation carriers who had an oophorectomy.Results: There was a small and non-significant difference in bodyweight between BRCA mutation carriers who had an oophorectomy compared with those women who did not (151.5 vs 149.1 pounds; p = 0.26). There was an increase in bodyweight with increasing age, but this relationship did not differ prior to and following surgery (p comparing the slope parameters = 0.78).Conclusion: Oophorectomy is not associated with significant weight gain in high-risk women.