Use of a bioartificial dermal regeneration template for skin restoration in combat casualty injuries. (January 2016)

• Record Type: Journal Article
• Authors: Seavey, Jonathan G; Masters, Zachary A; Balazs, George C; Tintle, Scott M; Sabino, Jennifer; Fleming, Mark E; Valerio, Ian L
• Is Part Of: Regenerative medicine. Volume 11:Number 1(2016)
• Page Start: 81
• Page End: 90
• Publication Date: 2016-01
• Subjects: amputation -- bioartificial dermal regeneration template -- bioartificial dermal substitute -- engineered dermis -- integra -- polytrauma wound management -- soft tissue coverage; Cellular therapy -- Periodicals; Stem cells -- Transplantation -- Periodicals; Degeneration (Pathology) -- Treatment -- Periodicals; Regeneration (Biology) -- Periodicals; 611.018
• DOI: 10.2217/rme.15.83
• Languages: English
• ISSNs: 1746-0751

Abstract

Military personnel who survive combat injuries frequently have large soft tissue wounds complicated by concomitant injuries and contamination. These devastating wounds present a therapeutic challenge to not only restore the protective skin barrier but also to preserve tendon and muscle excursion, provide protective padding around nerves and restore adequate joint motion. Accordingly, regenerative medicine modalities that can accomplish these goals are of great interest. The use of bioartificial dermal regeneration templates (DRT), such as Integra DRT (Integra Lifesciences Corporation, Plainsboro, NJ, USA), in the management of complex soft tissue injuries has an important role in the reconstruction of war wounds. These DRTs provide initial wound coverage and help establish a well-vascularized wound bed suitable for definitive soft tissue coverage.