Interleukin 17A rs2275913 polymorphism is associated with susceptibility to systemic lupus erythematosus: A meta and trial sequential analysis. (May 2022)

• Record Type: Journal Article
• Authors: Padhi, Sunali; Sarangi, Surjyapratap; Nayak, Nisha; Barik, Debashis; Pati, Abhijit; Panda, Aditya K
• Is Part Of: Lupus. Volume 31:Number 6(2022)
• Page Start: 674
• Page End: 683
• Publication Date: 2022-05
• Subjects: meta-analysis -- interleukin-17A -- systemic lupus erythematosus -- rs2275913 -- genetic predisposition; Systemic lupus erythematosus -- Periodicals; 616.772005
• DOI: 10.1177/09612033221090172
• Languages: English
• ISSNs: 0961-2033

Abstract

Background: The role of cytokines in the development of systemic lupus erythematosus (SLE) has received much attention. Interleukin-17 A upregulates several inflammation-related genes and is thought to have a crucial role in SLE development. The susceptibility to SLE development has been linked to functional genetic variations of the IL-17A gene; nevertheless, the findings have been conflicting. We conducted a meta-analysis that included previously published reports to establish a definitive conclusion on the role of the IL-17A rs2275913 polymorphism in SLE propensity. Materials and Methods: The PubMed, Google Scholar, and Scopus databases were used to find eligible published articles. All analyses were conducted using Comprehensive Meta-analysis V3.1. Funnel plots and Egger's regression analysis were used to assess publication bias. Q statistics and I 2 test explored the heterogeneity among the included studies. Combined odds ratio, 95% confidence interval were calculated for each comparison model. Results: Based on the inclusion and exclusion criteria, a total of four reports, comprising of 608 SLE patients and 815 healthy controls, were considered for the present meta-analysis. The homozygous comparison (AA vs. GG: combined odds ratio= 2.046, p = 0.005) and recessive genetic model (AA vs. GG+GA: combined odds ratio=1.901, p = 0.010) analysis revealed a significant association of rs2275913 with susceptibility to the development of SLE. However, other genetic comparisons (A vs. G, GA vs. GG, AA+GA vs. GG) failed to demonstrate such association. Furthermore, trial sequential analysis revealed a sufficient number of studies, including enough cases and controls that have already been considered to conclude the role of IL17-A rs2275913 polymorphism in SLE. Conclusions: IL-17A rs2275913 polymorphism is associated with susceptibility to SLE development.