Genetics, genomics and personalized medicine in Type 2 diabetes: a perspective on the Arab region. (August 2015)

• Record Type: Journal Article
• Authors: Siddiqui, Khalid; Tyagi, Shivani
• Is Part Of: Personalized medicine. Volume 12:Number 4(Year 2015)
• Page Start: 417
• Page End: 431
• Publication Date: 2015-08
• Subjects: genetic variants -- genome-wide association studies -- personalized medicine -- pharmacogenomics -- Type 2 diabetes; Pharmacogenomics -- Periodicals; Pharmacogenetics -- Periodicals; 615.19
• DOI: 10.2217/PME.15.11
• Languages: English
• ISSNs: 1741-0541

Abstract

Type 2 diabetes (T2D) is a wide-spread, chronic metabolic disorder, affecting millions of people worldwide. The epidemic of diabetes has placed a huge strain on public health, longevity and economy. T2D occurs as a result of both genetic and environmental factors and is heterogeneous in its presentation across individuals. This review gives an overview of the genetic variations identified by genome-wide association studies which predispose individuals to T2D and those which are responsible for variable drug response across patients, and the necessity to adopt a personalized approach to diabetes management. We also include a perspective on diabetes in Arabs, given the high incidence of T2D and consanguineous marriages, and the need to understand associated genetic components in this vulnerable population.