Impact of recipient ACE I/D genotype on kidney function in renal transplant patients: a meta-analysis of cross-sectional and longitudinal studies. (November 2015)

• Record Type: Journal Article
• Authors: Cargnin, Sarah; Quaglia, Marco; Canonico, Pier Luigi; Stratta, Piero; Terrazzino, Salvatore
• Is Part Of: Pharmacogenomics. Volume 16:Number 16(2015)
• Page Start: 1887
• Page End: 1902
• Publication Date: 2015-11
• Subjects: ACE -- allograft dysfunction -- meta-analysis -- polymorphisms -- renal transplantation; Pharmacogenomics -- Periodicals; 615.1
• DOI: 10.2217/pgs.15.119
• Languages: English
• ISSNs: 1462-2416

Abstract

Aim: To perform a systematic review and meta-analysis of studies evaluating the influence of recipient angiotensin-converting enzyme insertion/deletion (ACE I/D) polymorphism on kidney function in renal transplant recipients.Materials & methods: A comprehensive search was performed through PubMed, Web of Knowledge and Cochrane databases up to December 2014. The methodological quality of identified studies was assessed using the MINORS criteria.Results: A total of 15 studies evaluating the role of recipient ACE I/D were included in the meta-analysis. In overall analyzes and subsequent subgroup and sensitivity analyzes, no evidence emerged of an effect of ACE I/D on serum creatinine levels, creatinine clearance or glomerular filtration rate.Conclusion: Although further investigation is still needed to determine the role of donor ACE genotype, recipient ACE I/D does not play a significant role on kidney function in renal transplant patients.