Nanomedical innovation: the SEON-concept for an improved cancer therapy with magnetic nanoparticles. (November 2015)

• Record Type: Journal Article
• Authors: Lyer, Stefan; Tietze, Rainer; Unterweger, Harald; Zaloga, Jan; Singh, Raminder; Matuszak, Jasmin; Poettler, Marina; Friedrich, Ralf P; Duerr, Stephan; Cicha, Iwona; Janko, Christina; Alexiou, Christoph
• Is Part Of: Nanomedicine. Volume 10:Number 21(2015)
• Page Start: 3287
• Page End: 3304
• Publication Date: 2015-11
• Subjects: cancer -- chemotherapy -- drug delivery -- imaging -- iron oxide nanoparticles -- magnetic drug targeting -- nanomedicine -- nanotechnology -- oncology -- SEON-concept; Nanotechnology -- Periodicals; Medical technology -- Periodicals; Nanotechnology -- Therapeutic use -- Periodicals; 610.28
• DOI: 10.2217/nnm.15.159
• Languages: English
• ISSNs: 1743-5889

Abstract

Nanomedicine offers tremendous opportunities for the development of novel therapeutic and diagnostic tools. During the last decades, extensive knowledge was gained about stabilizing and the coating of nanoparticles, their functionalization for drug binding and drug release and possible strategies for therapies and diagnostics of different diseases. Most recently, more and more emphasis has been placed on nanotoxicology and nanosafety aspects. The section of experimental oncology and nanomedicine developed a concept for translating this knowledge into clinical application of magnetic drug targeting for the treatment of cancer and other diseases using superparamagnetic iron oxide nanoparticles. This approach includes reproducible synthesis, detailed characterization, nanotoxicological testing, evaluation in ex vivo models, preclinical animal studies and production of superparamagnetic iron oxide nanoparticles according to good manufacturing practice regulations.