Biomimetic approaches for cell implantation to the restoration of infarcted myocardium. (September 2015)

• Record Type: Journal Article
• Authors: Laiva, Ashang Luwang; Venugopal, Jayarama Reddy; Navaneethan, Balchandar; Karuppuswamy, Priyadharsini; Ramakrishna, Seeram
• Is Part Of: Nanomedicine. Volume 10:Number 18(2015)
• Page Start: 2907
• Page End: 2930
• Publication Date: 2015-09
• Subjects: biomaterials -- electrospun nanofibers -- injectable hydrogels -- myocardial infarction -- stem cell therapy; Nanotechnology -- Periodicals; Medical technology -- Periodicals; Nanotechnology -- Therapeutic use -- Periodicals; 610.28
• DOI: 10.2217/nnm.15.124
• Languages: English
• ISSNs: 1743-5889

Abstract

Compelling evidences accumulated over the years have proven stem cells as a promising source for regenerative medicine. However, the inadequacy with the design of delivery modalities has prolonged the research in realizing an ideal cell-based approach for the regeneration of infarcted myocardium. Currently, some modest improvements in cardiac function have been documented in clinical trials with stem cell treatments, although regenerating a fully functional myocardium remains a dream for cardiac surgeons. This review provides an overview on the significance of stem cell therapy, the current attempts to resolve the drawbacks with the cell implantation approach and the various stratagems adopted with electrospun hybrid nanofibers for implementation in myocardial regenerative therapy.