A story told by a single nanoparticle in the body fluid: demonstration of dissolution-reprecipitation of nanocrystals in a biological system. (September 2015)

• Record Type: Journal Article
• Authors: Wu, Cheng-Yeu; Young, David; Martel, Jan; Young, John D
• Is Part Of: Nanomedicine. Volume 10:Number 17(2015)
• Page Start: 2659
• Page End: 2676
• Publication Date: 2015-09
• Subjects: calcifying nanoparticles -- calciprotein particles -- ectopic calcification -- mineralo-organic nanoparticles -- nanobacteria -- serum granules; Nanotechnology -- Periodicals; Medical technology -- Periodicals; Nanotechnology -- Therapeutic use -- Periodicals; 610.28
• DOI: 10.2217/nnm.15.88
• Languages: English
• ISSNs: 1743-5889

Abstract

Aim: Analysis of the chemical composition of mineral particles found in the body is critical to understand the formation and effects of these entities in vivo . Yet, the possibility that biological fluids may modulate particle composition over time has not been examined.Materials & methods: Mineralo-organic nanoparticles similar to the ones that spontaneously form in human tissues were analyzed using electron microscopy, spectroscopy and proteomic analyses. Results: We show that the mineralo-organic nanoparticles assimilate various ions and minerals during incubation in ionic solutions simulating body fluids. The particles undergo dissolution-reprecipitation reactions that affect the final protein composition of the particles.Conclusion: The reactions occurring at the mineral-water interface therefore modulate the ionic and organic composition of mineral nanoparticles formed in biological fluids, producing changes that may alter the effects of mineral particles and stones in vivo .