Accumulation of amino-polyvinyl alcohol-coated superparamagnetic iron oxide nanoparticles in bone marrow: implications for local stromal cells. (July 2015)

• Record Type: Journal Article
• Authors: Schulze, Frank; Gramoun, Azza; Crowe, Lindsey A; Dienelt, Anke; Akcan, Tugba; Hofmann, Heinrich; Vallée, Jean-Paul; Duda, Georg N; Ode, Andrea
• Is Part Of: Nanomedicine. Volume 10:Number 14(2015)
• Page Start: 2139
• Page End: 2151
• Publication Date: 2015-07
• Subjects: bone marrow -- bone marrow stromal cells -- contrast enhancement -- MRI -- polyvinyl alcohol -- superparamagnetic iron oxide nanoparticles; Nanotechnology -- Periodicals; Medical technology -- Periodicals; Nanotechnology -- Therapeutic use -- Periodicals; 610.28
• DOI: 10.2217/nnm.15.62
• Languages: English
• ISSNs: 1743-5889

Abstract

Aims: First, it will be investigated if amino-polyvinyl alcohol-coated superparamagnetic iron oxide nanoparticles (A-PVA-SPIONs) are suitable for MRI contrast enhancement in bone marrow. Second, the impact of A-PVA-SPION exposure in vivo on the viability and key functions of local bone marrow stromal cells (BMSCs) will be investigated.Material & methods: Animals were systemically injected with A-PVA-SPIONs, followed by a 7-day survival time. Accumulation of A-PVA-SPIONs was confirmed by MRI, histology and inductively coupled plasma optical emission spectrometry. BMSCs were isolated from bone marrow for in vitro assessment of their viability and regenerative key functions.Results: In this study, A-PVA-SPIONs were found to accumulate in bone marrow and increase the BMSCs' metabolic activity and migration rate.Conclusion: A-PVA-SPIONs appear suitable for contrast enhancement in bone marrow while our data suggest an influence on the BMSCs biology that necessitates future research.