Sex‐ and age‐related differences in the management and outcomes of chronic heart failure: an analysis of patients from the ESC HFA EORP Heart Failure Long‐Term Registry. (20th December 2019)

• Record Type: Journal Article
• Authors: Lainščak, Mitja; Milinković, Ivan; Polovina, Marija; Crespo‐Leiro, Marisa G.; Lund, Lars H.; Anker, Stefan D.; Laroche, Cécile; Ferrari, Roberto; Coats, Andrew J.S.; McDonagh, Theresa; Filippatos, Gerasimos; Maggioni, Aldo P.; Piepoli, Massimo F.; Rosano, Giuseppe M.C.; Ruschitzka, Frank; Simić, Dragan; Ašanin, Milika; Eicher, Jean‐Christophe; Yilmaz, Mehmet B.; Seferović, Petar M.
• Other Names: Gale Christopher Peter investigator.; Chair GB investigator.; Branko Beleslin RS investigator.; Andrzej Budaj PL investigator.; Ovidiu Chioncel RO investigator.; Nikolaos Dagres DE investigator.; Nicolas Danchin FR investigator.; David Erlinge SE investigator.; Jonathan Emberson GB investigator.; Michael Glikson IL investigator.; Alastair Gray GB investigator.; Meral Kayikcioglu TR investigator.; Aldo Maggioni IT investigator.; Klaudia Vivien Nagy HU investigator.; Aleksandr Nedoshivin RU investigator.; Anna‐Sonia Petronio IT investigator.; Jolien Roos‐Hesselink NL investigator.; Lars Wallentin SE investigator.; Uwe Zeymer DE. investigator.; Crespo‐Leiro M. investigator.; Anker S. investigator.; Mebazaa A. investigator.; Coats A. investigator.; Filippatos G. investigator.; Ferrari R. investigator.; Maggioni A.P. investigator.; Piepoli M.F. investigator.; AL A. Goda investigator.; AR M. Diez investigator.; AR A. Fernandez investigator.; AT F. Fruhwald investigator.; Fazlibegovic E. investigator.; BG P. Gatzov investigator.; BY A. Kurlianskaya investigator.; CH R. Hullin investigator.; CY T. Christodoulides investigator.; CZ J. Hradec investigator.; DK O. Wendelboe Nielsen investigator.; DZ R. Nedjar investigator.; EE T. Uuetoa investigator.; EG M. Hassanein investigator.; ES J. F. Delgado Jimenez investigator.; FI V‐P. Harjola investigator.; FR D. Logeart investigator.; GE V. Chumburidze investigator.; GR D. Tousoulis investigator.; HR D. Milicic investigator.; HU B. Merkely investigator.; O'Donoghue IE E. investigator.; IL O. Amir investigator.; IL A. Shotan investigator.; IR D. Shafie investigator.; IT M. Metra investigator.; JP A. Matsumori investigator.; KG E. Mirrakhimov investigator.; LT A. Kavoliuniene investigator.; LV A. Erglis investigator.; Vataman E. investigator.; MK M. Otljanska investigator.; MK E. Srbinovska Kostovska investigator.; MT D. Cassar DeMarco investigator.; PL J. Drozdz investigator.; Fonseca C. investigator.; RO O. Chioncel investigator.; RS M. Dekleva investigator.; RU E. Shkolnik investigator.; SE U. Dahlstrom investigator.; SI M. Lainscak investigator.; SK E. Goncalvesova investigator.; TR A. Temizhan investigator.; UY V. Estrago investigator.; XK G. Bajraktari investigator.; Auer J. investigator.; Ablasser K. investigator.; Fruhwald F. investigator.; Dolze T. investigator.; Brandner K. investigator.; Gstrein S. investigator.; Poelzl G. investigator.; Moertl D. investigator.; Reiter S. investigator.; Podczeck‐Schweighofer A. investigator.; Muslibegovic A. investigator.; Vasilj M. investigator.; Fazlibegovic E. investigator.; Cesko M. investigator.; Zelenika D. investigator.; Palic B. investigator.; Pravdic D. investigator.; Cuk D. investigator.; Vitlianova K. investigator.; Katova T. investigator.; Velikov T. investigator.; Kurteva T. investigator.; Gatzov P. investigator.; Kamenova D. investigator.; Antova M. investigator.; Sirakova V. investigator.; Krejci J. investigator.; Mikolaskova M. investigator.; Spinar J. investigator.; Krupicka J. investigator.; Malek F. investigator.; Hegarova M. investigator.; Lazarova M. investigator.; Monhart Z. investigator.; Hassanein M. investigator.; Sobhy M. investigator.; El Messiry F. investigator.; El Shazly A.H. investigator.; Elrakshy Y. investigator.; Youssef A. investigator.; Moneim A.A. investigator.; Noamany M. investigator.; Reda A. investigator.; Dayem T.K. Abdel investigator.; Farag N. investigator.; Halawa S. Ibrahim investigator.; Hamid M. Abdel investigator.; Said K. investigator.; Saleh A. investigator.; Ebeid H. investigator.; Hanna R. investigator.; Aziz R. investigator.; Louis O. investigator.; Enen M.A. investigator.; Ibrahim B.S. investigator.; Nasr G. investigator.; Elbahry A. investigator.; Sobhy H. investigator.; Ashmawy M. investigator.; Gouda M. investigator.; Aboleineen W. investigator.; Bernard Y. investigator.; Luporsi P. investigator.; Meneveau N. investigator.; Pillot M. investigator.; Morel M. investigator.; Seronde M‐F. investigator.; Schiele F. investigator.; Briand F. investigator.; Delahaye F. investigator.; Damy T. investigator.; Eicher J‐C. investigator.; de Groote P. investigator.; Fertin M. investigator.; Lamblin N. investigator.; Isnard R. investigator.; Lefol C. investigator.; Thevenin S. investigator.; Hagege A. investigator.; Jondeau G. investigator.; Logeart D. investigator.; Le Marcis V. investigator.; Ly J‐F. investigator.; Coisne D. investigator.; Lequeux B. investigator.; Le Moal V. investigator.; Mascle S. investigator.; Lotton P. investigator.; Behar N. investigator.; Donal E. investigator.; Thebault C. investigator.; Ridard C. investigator.; Reynaud A. investigator.; Basquin A. investigator.; Bauer F. investigator.; Codjia R. investigator.; Galinier M. investigator.; Tourikis P. investigator.; Stavroula M. investigator.; Tousoulis D. investigator.; Stefanadis C. investigator.; Chrysohoou C. investigator.; Kotrogiannis I. investigator.; Matzaraki V. investigator.; Dimitroula T. investigator.; Karavidas A. investigator.; Tsitsinakis G. investigator.; Kapelios C. investigator.; Nanas J. investigator.; Kampouri H. investigator.; Nana E. investigator.; Kaldara E. investigator.; Eugenidou A. investigator.; Vardas P. investigator.; Saloustros I. investigator.; Patrianakos A. investigator.; Tsaknakis T. investigator.; Evangelou S. investigator.; Nikoloulis N. investigator.; Tziourganou H. investigator.; Tsaroucha A. investigator.; Papadopoulou A. investigator.; Douras A. investigator.; Polgar L. investigator.; Merkely B. investigator.; Kosztin A. investigator.; Nyolczas N. investigator.; Nagy A. Csaba investigator.; Halmosi R. investigator.; Elber J. investigator.; Alony I. investigator.; Shotan A. investigator.; Fuhrmann A. Vazan investigator.; Amir O. investigator.; Romano S. investigator.; Marcon S. investigator.; Penco M. investigator.; Di Mauro M. investigator.; Lemme E. investigator.; Carubelli V. investigator.; Rovetta R. investigator.; Metra M. investigator.; Bulgari M. investigator.; Quinzani F. investigator.; Lombardi C. investigator.; Bosi S. investigator.; Schiavina G. investigator.; Squeri A. investigator.; Barbieri A. investigator.; Di Tano G. investigator.; Pirelli S. investigator.; Ferrari R. investigator.; Fucili A. investigator.; Passero T. investigator.; Musio S. investigator.; Di Biase M. investigator.; Correale M. investigator.; Salvemini G. investigator.; Brognoli S. investigator.; Zanelli E. investigator.; Giordano A. investigator.; Agostoni P. investigator.; Italiano G. investigator.; Salvioni E. investigator.; Copelli S. investigator.; Modena M.G. investigator.; Reggianini L. investigator.; Valenti C. investigator.; Olaru A. investigator.; Bandino S. investigator.; Deidda M. investigator.; Mercuro G. investigator.; Dessalvi C. 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Ausilia investigator.; Teresi G. investigator.; Buccheri D. investigator.; Minacapelli A. investigator.; Veniani M. investigator.; Frisinghelli A. investigator.; Priori S.G. investigator.; Cattaneo S. investigator.; Opasich C. investigator.; Gualco A. investigator.; Pagliaro M. investigator.; Mancone M. investigator.; Fedele F. investigator.; Cinque A. investigator.; Vellini M. investigator.; Scarfo I. investigator.; Romeo F. investigator.; Ferraiuolo F. investigator.; Sergi D. investigator.; Anselmi M. investigator.; Melandri F. investigator.; Leci E. investigator.; Iori E. investigator.; Bovolo V. investigator.; Pidello S. investigator.; Frea S. investigator.; Bergerone S. investigator.; Botta M. investigator.; Canavosio F.G. investigator.; Gaita F. investigator.; Merlo M. investigator.; Cinquetti M. investigator.; Sinagra G. investigator.; Ramani F. investigator.; Fabris E. investigator.; Stolfo D. investigator.; Artico J. investigator.; Miani D. investigator.; Fresco C. investigator.; Daneluzzi C. investigator.; Proclemer A. investigator.; Cicoira M. investigator.; Zanolla L. investigator.; Marchese G. investigator.; Torelli F. investigator.; Vassanelli C. investigator.; Voronina N. investigator.; Erglis A. investigator.; Tamakauskas V. investigator.; Smalinskas V. investigator.; Karaliute R. investigator.; Petraskiene I. investigator.; Kazakauskaite E. investigator.; Rumbinaite E. investigator.; Kavoliuniene A. investigator.; Vysniauskas V. investigator.; Brazyte‐Ramanauskiene R. investigator.; Petraskiene D. investigator.; Stankala S. investigator.; Switala P. investigator.; Juszczyk Z. investigator.; Sinkiewicz W. investigator.; Gilewski W. investigator.; Pietrzak J. investigator.; Orzel T. investigator.; Kasztelowicz P. investigator.; Kardaszewicz P. investigator.; Lazorko‐Piega M. investigator.; Gabryel J. investigator.; Mosakowska K. investigator.; Bellwon J. investigator.; Rynkiewicz A. investigator.; Raczak G. investigator.; Lewicka E. investigator.; Dabrowska‐Kugacka A. investigator.; Bartkowiak R. investigator.; Sosnowska‐Pasiarska B. investigator.; Wozakowska‐Kaplon B. investigator.; Krzeminski A. investigator.; Zabojszcz M. investigator.; Mirek‐Bryniarska E. investigator.; Grzegorzko A. investigator.; Bury K. investigator.; Nessler J. investigator.; Zalewski J. investigator.; Furman A. investigator.; Broncel M. investigator.; Poliwczak A. investigator.; Bala A. investigator.; Zycinski P. investigator.; Rudzinska M. investigator.; Jankowski L. investigator.; Kasprzak J.D. investigator.; Michalak L. investigator.; Soska K. Wojtczak investigator.; Drozdz J. investigator.; Huziuk I. investigator.; Retwinski A. investigator.; Flis P. investigator.; Weglarz J. investigator.; Bodys A. investigator.; Grajek S. investigator.; Kaluzna‐Oleksy M. investigator.; Straburzynska‐Migaj E. investigator.; Dankowski R. investigator.; Szymanowska K. investigator.; Grabia J. investigator.; Szyszka A. investigator.; Nowicka A. investigator.; Samcik M. investigator.; Wolniewicz L. investigator.; Baczynska K. investigator.; Komorowska K. investigator.; Poprawa I. investigator.; Komorowska E. investigator.; Sajnaga D. investigator.; Zolbach A. investigator.; Dudzik‐Plocica A. investigator.; Abdulkarim A‐F. investigator.; Lauko‐Rachocka A. investigator.; Kaminski L. investigator.; Kostka A. investigator.; Cichy A. investigator.; Ruszkowski P. investigator.; Splawski M. investigator.; Fitas G. investigator.; Szymczyk A. investigator.; Serwicka A. investigator.; Fiega A. investigator.; Zysko D. investigator.; Krysiak W. investigator.; Szabowski S. investigator.; Skorek E. investigator.; Pruszczyk P. investigator.; Bienias P. investigator.; Ciurzynski M. investigator.; Welnicki M. investigator.; Mamcarz A. investigator.; Folga A. investigator.; Zielinski T. investigator.; Rywik T. investigator.; Leszek P. investigator.; Sobieszczanska‐Malek M. investigator.; Piotrowska M. investigator.; Kozar‐Kaminska K. investigator.; Komuda K. investigator.; Wisniewska J. investigator.; Tarnowska A. investigator.; Balsam P. investigator.; Marchel M. investigator.; Opolski G. investigator.; Kaplon‐Cieslicka A. investigator.; Gil R.J. investigator.; Mozenska O. investigator.; Byczkowska K. investigator.; Gil K. investigator.; Pawlak A. investigator.; Michalek A. investigator.; Krzesinski P. investigator.; Piotrowicz K. investigator.; Uzieblo‐Zyczkowska B. investigator.; Stanczyk A. investigator.; Skrobowski A. investigator.; Ponikowski P. investigator.; Jankowska E. investigator.; Rozentryt P. investigator.; Polonski L. investigator.; Gadula‐Gacek E. investigator.; Nowalany‐Kozielska E. investigator.; Kuczaj A. investigator.; Kalarus Z. investigator.; Szulik M. investigator.; Przybylska K. investigator.; Klys J. investigator.; Prokop‐Lewicka G. investigator.; Kleinrok A. investigator.; Aguiar C. 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Suzic investigator.; Stojcevski B. investigator.; Pencic B. investigator.; Stevanovic A. investigator.; Andric A. investigator.; Simić Dragan investigator.; Ašanin Milika investigator.; Iric‐Cupic V. investigator.; Jovic M. investigator.; Davidovic G. investigator.; Milanov S. investigator.; Mitic V. investigator.; Atanaskovic V. investigator.; Antic S. investigator.; Pavlovic M. investigator.; Stanojevic D. investigator.; Stoickov V. investigator.; Ilic S. investigator.; Ilic M. Deljanin investigator.; Petrovic D. investigator.; Stojsic S. investigator.; Kecojevic S. investigator.; Dodic S. investigator.; Adic N. Cemerlic investigator.; Cankovic M. investigator.; Stojiljkovic J. investigator.; Mihajlovic B. investigator.; Radin A. investigator.; Radovanovic S. investigator.; Krotin M. investigator.; Klabnik A. investigator.; Goncalvesova E. investigator.; Pernicky M. investigator.; Murin J. investigator.; Kovar F. investigator.; Kmec J. investigator.; Semjanova H. investigator.; Strasek M. investigator.; Iskra M. Savnik investigator.; Ravnikar T. investigator.; Suligoj N. Cernic investigator.; Komel J. investigator.; Fras Z. investigator.; Jug B. investigator.; Glavic T. investigator.; Losic R. investigator.; Bombek M. investigator.; Krajnc I. investigator.; Krunic B. investigator.; Horvat S. investigator.; Kovac D. investigator.; Rajtman D. investigator.; Cencic V. investigator.; Letonja M. investigator.; Winkler R. investigator.; Valentincic M. investigator.; Melihen‐Bartolic C. investigator.; Bartolic A. investigator.; Vrckovnik M. Pusnik investigator.; Kladnik M. investigator.; Pusnik C. Slemenik investigator.; Marolt A. investigator.; Klen J. investigator.; Drnovsek B. investigator.; Leskovar B. investigator.; Anguita M.J. Fernandez investigator.; Page J.C. Gallego investigator.; Martinez F.M. Salmeron investigator.; Andres J. investigator.; Bayes‐Genis A. investigator.; Mirabet S. investigator.; Mendez A. investigator.; Garcia‐Cosio L. investigator.; Roig E. investigator.; Leon V. investigator.; Gonzalez‐Costello J. investigator.; Muntane G. investigator.; Garay A. investigator.; Alcade‐Martinez V. investigator.; Fernandez S. Lopez investigator.; Rivera‐Lopez R. investigator.; Puga‐Martinez M. investigator.; Fernandez‐Alvarez M. investigator.; Serrano‐Martinez J.L. investigator.; Crespo‐Leiro M. investigator.; Grille‐Cancela Z. investigator.; Marzoa‐Rivas R. investigator.; Blanco‐Canosa P. investigator.; Paniagua‐Martin M.J. investigator.; Barge‐Caballero E. investigator.; Cerdena I. Laynez investigator.; Baldomero I. Famara Hernandez investigator.; Padron A. Lara investigator.; Rosillo S. Ofelia investigator.; Gonzalez‐Gallarza R. Dalmau investigator.; Montanes O. Salvador investigator.; Manjavacas A.M. Iniesta investigator.; Conde A. Castro investigator.; Araujo A. investigator.; Soria T. investigator.; Garcia‐Pavia P. investigator.; Gomez‐Bueno M. investigator.; Cobo‐Marcos M. investigator.; Alonso‐Pulpon L. investigator.; Cubero J. Segovia investigator.; Sayago I. investigator.; Gonzalez‐Segovia A. investigator.; Briceno A. investigator.; Subias P. Escribano investigator.; Hernandez M. Vicente investigator.; Cano M.J. Ruiz investigator.; Sanchez M.A. Gomez investigator.; Jimenez J.F. Delgado investigator.; Garrido‐Lestache E. Barrios investigator.; Pinilla J.M. Garcia investigator.; de la Villa B. Garcia investigator.; Sahuquillo A. investigator.; Marques R. Bravo investigator.; Calvo F. Torres investigator.; Perez‐Martinez M.T. investigator.; Gracia‐Rodenas M.R. investigator.; Garrido‐Bravo I. P. investigator.; Pastor‐Perez F. investigator.; Pascual‐Figal D.A. investigator.; Molina B. Diaz investigator.; Orus J. investigator.; Gonzalo F. Epelde investigator.; Bertomeu V. investigator.; Valero R. investigator.; Martinez‐Abellan R. investigator.; Quiles J. investigator.; Rodrigez‐Ortega J.A. investigator.; Mateo I. investigator.; ElAmrani A. investigator.; Fernandez‐Vivancos C. investigator.; Valero D. Bierge investigator.; Almenar‐Bonet L. investigator.; Sanchez‐Lazaro I.J. investigator.; Marques‐Sule E. investigator.; Facila‐Rubio L. investigator.; Perez‐Silvestre J. investigator.; Garcia‐Gonzalez P. investigator.; Ridocci‐Soriano F. investigator.; Garcia‐Escriva D. investigator.; Pellicer‐Cabo A. investigator.; de la Fuente Galan L. investigator.; Diaz J. Lopez investigator.; Platero A. Recio investigator.; Arias J.C. investigator.; Blasco‐Peiro T. investigator.; Julve M. Sanz investigator.; Sanchez‐Insa E. investigator.; Aured‐Guallar C. investigator.; Portoles‐Ocampo A. investigator.; Melin M. investigator.; Hägglund E. investigator.; Stenberg A. investigator.; Lindahl I‐M. investigator.; Asserlund B. investigator.; Olsson L. investigator.; Dahlström U. investigator.; Afzelius M. investigator.; Karlström P. investigator.; Tengvall L. investigator.; Wiklund P‐A. investigator.; Olsson B. investigator.; Kalayci S. investigator.; Temizhan A. investigator.; Cavusoglu Y. investigator.; Gencer E. investigator.; Yilmaz M.B. investigator.; Gunes H. investigator.;
• Is Part Of: European journal of heart failure. Volume 22:Number 1(2020)
• Page Start: 92
• Page End: 102
• Publication Date: 2019-12-20
• Subjects: Age -- Sex -- Mortality -- Hospitalization -- Registry; Heart failure -- Periodicals; Heart Failure -- Periodicals; Insuffisance cardiaque -- Périodiques; Heart failure; Periodicals; 616.129005
• DOI: 10.1002/ejhf.1645
• Languages: English
• ISSNs: 1388-9842

Abstract

Abstract: Aims: This study aimed to assess age‐ and sex‐related differences in management and 1‐year risk for all‐cause mortality and hospitalization in chronic heart failure (HF) patients. Methods and results: Of 16 354 patients included in the European Society of Cardiology Heart Failure Long‐Term Registry, 9428 chronic HF patients were analysed [median age: 66 years; 28.5% women; mean left ventricular ejection fraction (LVEF) 37%]. Rates of use of guideline‐directed medical therapy (GDMT) were high (angiotensin‐converting enzyme inhibitors/angiotensin receptor blockers, beta‐blockers and mineralocorticoid receptor antagonists: 85.7%, 88.7% and 58.8%, respectively). Crude GDMT utilization rates were lower in women than in men (all differences: P ≤ 0.001), and GDMT use became lower with ageing in both sexes, at baseline and at 1‐year follow‐up. Sex was not an independent predictor of GDMT prescription; however, age >75 years was a significant predictor of GDMT underutilization. Rates of all‐cause mortality were lower in women than in men (7.1% vs. 8.7%; P = 0.015), as were rates of all‐cause hospitalization (21.9% vs. 27.3%; P < 0.001) and there were no differences in causes of death. All‐cause mortality and all‐cause hospitalization increased with greater age in both sexes. Sex was not an independent predictor of 1‐year all‐cause mortality (restricted to patients with LVEF ≤45%). Mortality risk was significantly lower in patients of younger age, compared to patients aged >75 years. Conclusions: There was a decline in GDMT use with advanced age in both sexes. Sex was not an independent predictor of GDMT or adverse outcomes. However, age >75 years independently predicted lower GDMT use and higher all‐cause mortality in patients with LVEF ≤45%.