Treatment of hepatitis C in coinfected patients. (December 2015)

• Record Type: Journal Article
• Authors: Bello, David Del; Ita-Nagy, Fanny; Hand, Jonathan; Dieterich, Douglas
• Is Part Of: Future virology. Volume 10:Number 12(2015)
• Page Start: 1291
• Page End: 1305
• Publication Date: 2015-12
• Subjects: coinfection -- direct-acting antivirals -- hepatitis C -- HIV; Virology -- Periodicals; Virus diseases -- Treatment -- Periodicals; 616.9101
• DOI: 10.2217/fvl.15.99
• Languages: English
• ISSNs: 1746-0794

Abstract

HCV and liver disease have emerged as major causes of morbidity and mortality in HIV-positive patients. Treating HCV in patients with HIV has been challenging up until a few years ago due to poorer outcomes with interferon-based therapies in this population. The direct-acting antiviral (DAA) agents offer a new era in the treatment of HCV for all patients regardless of HIV status. This article reviews multiple aspects of the care of the coinfected patient with a focus on the modern DAA agents. HCV clinical treatment trials involving HIV-positive patients and antiretroviral therapy/DAA drug–drug interactions are reviewed in detail.