Analysis of amino acid changes in NS protein of influenza A/(H3N2) virus in Iranian isolates. (November 2015)

• Record Type: Journal Article
• Authors: Dahiru Rogo, Lawal; Rezaei, Farhad; Shafiei-Jandaghi, Nazanin Z; Ghavami, Nastaran; Fatemi-Nasab, Ghazal; Mokhtari-Azad, Talat
• Is Part Of: Future virology. Volume 10:Number 11(2015)
• Page Start: 1195
• Page End: 1206
• Publication Date: 2015-11
• Subjects: influenza A (H3N2) virus -- Iran -- mutation -- NS gene; Virology -- Periodicals; Virus diseases -- Treatment -- Periodicals; 616.9101
• DOI: 10.2217/fvl.15.90
• Languages: English
• ISSNs: 1746-0794

Abstract

Aim: Roles of NS gene of influenza A virus in virulence and replication are well established but extent of its variation in seasonal influenza A (H3N2) viruses in Iran is not well known.Materials & methods: NS gene of 37 (A/H3N2) virus isolates were sequenced and analyzed for information on genetic changes.Results: Data analysis of NS1 protein revealed two amino acid substitutions E26K and Q193R in almost all strains. Substitutions in T58P in 27.0%, A86S in 13.5% and each of V11G, M81I and P85T in 2.7% Iranian strains were also observed. Mutations in NS2/NEP protein were observed in K36E, Q101L and F107S.Conclusion: Many mutations were observed for the first time in Iranian strains. Their function remains to be determined.