Standardized data collection to build prediction models in oncology: a prototype for rectal cancer. (January 2016)

• Record Type: Journal Article
• Authors: Meldolesi, Elisa; van Soest, Johan; Damiani, Andrea; Dekker, Andre; Alitto, Anna Rita; Campitelli, Maura; Dinapoli, Nicola; Gatta, Roberto; Gambacorta, Maria Antonietta; Lanzotti, Vito; Lambin, Philippe; Valentini, Vincenzo
• Is Part Of: Future oncology. Volume 12:Number 1(2016)
• Page Start: 119
• Page End: 136
• Publication Date: 2016-01
• Subjects: Big Data -- data standardization -- decision support system -- ontology -- predictive models -- semantic web -- umbrella protocol; Oncology -- Periodicals; 616.99405
• DOI: 10.2217/fon.15.295
• Languages: English
• ISSNs: 1479-6694

Abstract

The advances in diagnostic and treatment technology are responsible for a remarkable transformation in the internal medicine concept with the establishment of a new idea of personalized medicine. Inter- and intra-patient tumor heterogeneity and the clinical outcome and/or treatment's toxicity's complexity, justify the effort to develop predictive models from decision support systems. However, the number of evaluated variables coming from multiple disciplines: oncology, computer science, bioinformatics, statistics, genomics, imaging, among others could be very large thus making traditional statistical analysis difficult to exploit. Automated data-mining processes and machine learning approaches can be a solution to organize the massive amount of data, trying to unravel important interaction. The purpose of this paper is to describe the strategy to collect and analyze data properly for decision support and introduce the concept of an 'umbrella protocol' within the framework of 'rapid learning healthcare'.