Extending the reservoir of blaIMP-5: the emerging pathogen Acinetobacter bereziniae. (October 2015)

• Record Type: Journal Article
• Authors: Grosso, Filipa; Silva, Liliana; Sousa, Clara; Ramos, Helena; Quinteira, Sandra; Peixe, Luísa
• Is Part Of: Future microbiology. Volume 10:Number 10(2015:Oct.)
• Page Start: 1609
• Page End: 1613
• Publication Date: 2015-10
• Subjects: Acinetobacter bereziniae -- carbapenem resistance -- IMP-5 -- integron -- metallo-β-lactamase -- oxacillinase; Microbiology -- Research -- Periodicals; 616.9041
• DOI: 10.2217/fmb.15.88
• Languages: English
• ISSNs: 1746-0913

Abstract

Aim: Acinetobacter bereziniae clinical relevance is starting to be recognized; however, very few descriptions of its carbapenem resistance currently exist. Here we characterize two carbapenem-resistant A. bereziniae isolates.Materials & methods: Isolates were obtained from environmental and clinical samples. Carbapenemases were searched by phenotypic, biochemical and PCR assays. Clonality was studied by ApaI-PFGE and genetic location for carbapenemase genes were assessed by I-CeuI and S1 hybridizations.Results: Isolates were not clonally related but both produced the 'exclusively Portuguese' IMP-5, with the clinical isolate also producing an OXA-58. The carbapenemase genes were plasmid located.Conclusion: Our results emphasize the role of non- baumannii Acinetobacter species as important reservoirs of clinically relevant resistance genes that could also contribute to their emergence as nosocomial pathogens.