Epigenomic landscape of melanoma progression to brain metastasis: unexplored therapeutic alternatives. (December 2015)

• Record Type: Journal Article
• Authors: Marzese, Diego M; Witz, Isaac P; Kelly, Daniel F; Hoon, Dave SB
• Is Part Of: Epigenomics. Volume 7:Number 8(2015)
• Page Start: 1303
• Page End: 1311
• Publication Date: 2015-12
• Subjects: cancer progression -- chromatin modifications -- DNA methylation -- epigenomics -- melanoma brain metastasis -- metastasis microenvironment -- noncoding RNA expression -- regulatory elements; Epigenesis -- Periodicals; Genomics -- Periodicals; Chromatin -- Periodicals; DNA -- Periodicals; 572.87
• DOI: 10.2217/epi.15.77
• Languages: English
• ISSNs: 1750-1911

Abstract

Melanoma brain metastasis is a complication with rising incidence. Despite the high rate of somatic mutations driving the initial stages of melanocyte transformation, the brain colonization requires a phenotypic reprogramming that is, in part, influenced by epigenomic modifications. This special report summarizes recent findings in the epigenomic landscape of melanoma progression to brain metastasis, with particular emphasis on the clinical utility of DNA methylation, chromatin modifications and ncRNA expression as theragnostic markers, as well as the significance of the metastatic microenvironment on melanoma brain metastasis epigenome.