RIFM fragrance ingredient safety assessment, (2-endo, 3-exo)-ethyl 3-(1-methylethyl)bicyclo[2.2.1]hept-5-ene-2-carboxylate, CAS registry number 116044-44-1. (December 2021) - Api, A.M.
Highlights: (2-endo, 3-exo)-Ethyl 3-(1-methylethyl)bicyclo[2.2.1]hept-5-ene-2-carboxylate; a safety assessment based on RIFM's criteria. Based on 7 human health endpoints plus environmental. All endpoints were cleared using target data, read-across, and/or TTC. Abstract : In addition, the total systemic exposure to (2-endo, 3-exo)-ethyl 3-(1-methylethyl)bicyclo[2.2.1]hept-5-ene-2-carboxylate (3.3 μg/kg/day) is below the TTC (9 μg/kg/day; Kroes, 2007) for the repeated dose toxicity endpoint of a Cramer Class II material at the current level of use.