The association between bisphenol A exposure and oxidative damage in rats/mice: A systematic review and meta-analysis. (1st January 2022)

• Record Type: Journal Article
• Authors: Zhang, Huan; Yang, Ruifu; Shi, Wanying; Zhou, Xin; Sun, Suju
• Is Part Of: Environmental pollution. Volume 292:Part B(2022)
• Publication Date: 2022-01-01
• Subjects: Bisphenol A -- Oxidative damage -- Rats/mice -- Systematic review -- Meta-analysis; BPA Bisphenol A -- BPAF Bisphenol AF -- BPS Bisphenol S -- BPF Bisphenol F -- BPB Bisphenol B -- ROS Reactive oxygen species -- MDA Malondialdehyde -- H2O2 Hydrogen peroxide -- GSSG Glutathione disulfide -- SOD Superoxide dismutase -- GST Glutathione-s-transferase -- CAT Catalase -- GSH Glutathione -- GPx Glutathione peroxidase -- GR Glutathione reductase -- EU European union -- URSA Unexplained recurrent spontaneous abortion; Pollution -- Periodicals; Pollution -- Environmental aspects -- Periodicals; Environmental Pollution -- Periodicals; Pollution -- Périodiques; Pollution -- Aspect de l'environnement -- Périodiques; Pollution -- Effets physiologiques -- Périodiques; Pollution; Pollution -- Environmental aspects; Periodicals; Electronic journals; 363.73
• DOI: 10.1016/j.envpol.2021.118444
• Languages: English
• ISSNs: 0269-7491

Abstract

Abstract: Numerous studies reported that BPA could cause oxidative damage to different tissues in rats/mice. This study aimed to perform a systematic review and meta-analysis of BPA exposure on oxidative damage in rats/mice. A comprehensive literature search was conducted using PubMed, Embase, and Web of Science databases from their inception date until July 18, 2020. 20 eligible articles were included in this study. The results showed that BPA could significantly increase the level of MDA (SMD, 16.88; 95%CI, 12.06–21.71), but there was a significant reduction in the contents of antioxidants, such as GR (−10.46, −13.91 ∼ −7.02), CAT (−8.48, −11.66 ∼ −5.30), GPx (−9.37, −11.95 ∼ −6.80), GST (−7.59, −14.51 ∼ −0.67), GSH (−10.64, −13.96 ~ −7.33), and SOD (−6.48, −8.37 ∼ −4.58) in rats/mice. Our study provided clear evidence that BPA exposure could significantly induce oxidative damage in rats/mice. And we also found that the degree of oxidative damage was related to BPA dose, target tissue, intervention means, and exposure duration of BPA. Graphical abstract: Image 1 Highlights: BPA could cause oxidative damage by significantly increasing oxidant levels and reducing antioxidant levels in rats/mice. Tissue type in rats/mice, BPA intervention means, dose, and duration were related to oxidative damage indicators levels. The results provided clear evidence for the clarification and prevention of BPA-induced oxidative damage.