Environmental chemical risk factors for Type 2 diabetes: an update. (July 2015)

• Record Type: Journal Article
• Authors: Starling, Anne P; Hoppin, Jane A
• Is Part Of: Diabetes management. Volume 5:Number 4(2015)
• Page Start: 285
• Page End: 299
• Publication Date: 2015-07
• Subjects: air pollution -- arsenic -- bisphenol A -- dioxin -- environmental tobacco smoke -- persistent organic pollutant -- pesticide -- phthalate -- polychlorinated biphenyl; Diabetes -- Periodicals; 616.462005
• DOI: 10.2217/dmt.15.16
• Languages: English
• ISSNs: 1758-1915

Abstract

SUMMARY : Increasing evidence suggests a role for environmental chemicals in the promotion of Type 2 diabetes. This review summarizes epidemiologic studies of environmental chemical exposures reported to be associated with Type 2 diabetes and insulin resistance. Chemicals are classified as having moderate, limited and insufficient degrees of evidence in support of a diabetes-promoting effect. Moderate evidence exists for diabetogenic effects of inorganic arsenic and persistent organic pollutants, including organochlorines, dioxins and polychlorinated biphenyls. Limited evidence supports a role for environmental tobacco smoke and ambient air pollution. Insufficient evidence is available regarding the potential effects of bisphenol A, phthalates, organophosphates and pyrethroids; most studies of such short-lived pollutants have been cross-sectional and do not demonstrate causality.