Reducing Overuse of Proton Pump Inhibitors for Stress Ulcer Prophylaxis and Nonvariceal Gastrointestinal Bleeding in the Hospital: A Narrative Review and Implementation Guide. Issue 7 (16th June 2021)

• Record Type: Journal Article
• Authors: Clarke, Karen; Adler, Nicole; Agrawal, Deepak; Bhakta, Dimpal; Sata, Suchita Shah; Singh, Sarguni; Gupta, Arjun; Pahwa, Amit; Pherson, Emily; Sun, Alexander; Volpicelli, Frank; Sreenivasan, Aditya; Cho, Hyung J
• Is Part Of: Journal of hospital medicine. Volume 16:Issue 7(2021)
• Page Start: 417
• Page End: 423
• Publication Date: 2021-06-16
• Subjects: Hospital care -- Periodicals; Clinical medicine -- Periodicals; 610
• DOI: 10.12788/jhm.3637
• Languages: English
• ISSNs: 1553-5592

Abstract

Abstract : Proton pump inhibitors (PPIs) are among the most commonly used medications in the world; however, these drugs carry the risk of patient harm, including acute and chronic kidney disease, Clostridium difficile infection, hypomagnesemia, and fractures. In the hospital setting, PPIs are overused for stress ulcer prophylaxis and gastrointestinal bleeding, and PPI use often continues after discharge. Numerous multifaceted interventions have demonstrated safe and effective reduction of PPI use in the inpatient setting. This narrative review and the resulting implementation guide summarize published interventions to reduce inappropriate PPI use and provide a strategy for quality improvement teams.