Molecular background of oligodendroglioma: 1p/19q, IDH, TERT, CIC and FUBP1. (October 2015)

• Record Type: Journal Article
• Authors: Cahill, Daniel P; Louis, David N; Cairncross, John Gregory
• Is Part Of: CNS oncology. Volume 4:Number 5(2015)
• Page Start: 287
• Page End: 294
• Publication Date: 2015-10
• Subjects: 1p/19q loss -- CIC mutation -- FUBP1 mutation -- IDH mutation -- oligodendroglioma -- TERT mutation; Central nervous system -- Tumors -- Periodicals; 616.99481
• DOI: 10.2217/cns.15.32
• Languages: English
• ISSNs: 2045-0907

Abstract

Oligodendroglioma is the quintessential molecularly-defined brain tumor. The characteristic whole-arm loss of the long arm of chromosome 1 and the short arm of chromosome 19 (1p/19q-codeletion) within the genome of these tumors facilitated the reproducible molecular identification of this subcategory of gliomas. More recently, recurrent molecular genetic alterations have been identified to occur concurrently with 1p/19q-codeletion, and definitively identify these tumors, including mutations in IDH1/2, CIC, FUBP1, and the TERT promoter, as well as the absence of ATRX and TP53 alterations. These findings provide a foundation for the consistent diagnosis of this tumor type, upon which a generation of clinical investigators have assembled a strong evidence base for the effective treatment of this disease with radiation and chemotherapy.