Cardiolipin alterations and mitochondrial dysfunction in heart ischemia/reperfusion injury. (October 2015)

• Record Type: Journal Article
• Authors: Paradies, Giuseppe; Paradies, Valeria; Ruggiero, Francesca M; Petrosillo, Giuseppe
• Is Part Of: Clinical lipidology. Volume 10:Number 5(2015)
• Page Start: 415
• Page End: 429
• Publication Date: 2015-10
• Subjects: cardiolipin -- heart ischemia/reperfusion injury -- mitochondrial bioenergetics; Lipids -- Periodicals; 616.3997
• DOI: 10.2217/clp.15.31
• Languages: English
• ISSNs: 1758-4299

Abstract

Mitochondrial dysfunction is centrally involved in heart ischemia/reperfusion (I/R) injury. Increased reactive oxygen species production, impaired respiratory chain complexes activity and opening of the mitochondrial permeability transition pore have been suggested as possible factors responsible for mitochondrial dysfunction in heart I/R injury. Cardiolipin (CL), a phospholipid of the inner mitochondrial membrane, plays an important role in mitochondrial bioenergetics. CL alterations have been shown to play a causative role in mitochondrial dysfunction in a variety of pathological conditions, as well as in cell death. The role of CL alterations in mitochondrial dysfunction in heart I/R injury is here reviewed. Several cardioprotective strategies to prevent myocardial injury during I/R targeting mitochondrial CL are also examined.