Cardiovascular risk in pediatric nonalcoholic fatty liver disease: recent advances. (August 2015)

• Record Type: Journal Article
• Authors: Baskar, Shankar; Jhaveri, Simone; Alkhouri, Naim
• Is Part Of: Clinical lipidology. Volume 10:Number 4(2015)
• Page Start: 351
• Page End: 362
• Publication Date: 2015-08
• Subjects: cardiovascular diseases -- dyslipidemias -- fatty liver -- genetic -- inflammation -- insulin resistance -- metabolic syndrome -- nonalcoholic fatty liver disease -- oxidative stress -- pediatric obesity -- polymorphism; Lipids -- Periodicals; 616.3997
• DOI: 10.2217/clp.15.26
• Languages: English
• ISSNs: 1758-4299

Abstract

Nonalcoholic fatty liver disease (NAFLD) is the most common form of pediatric chronic liver disease in developed countries. NAFLD has risen to epidemic proportions paralleling that of childhood obesity. It is becoming increasingly evident that NAFLD is strongly linked with cardiovascular disease (CVD), which is the leading cause of mortality in the adult NAFLD population. It is very important for physicians caring for children being cognizant of the potential role of childhood NAFLD as an independent risk factor for CVD. Childhood is a time period where subclinical CVD can be detected, giving us the potential ability to halt or reverse the disease process. In this review, we discuss recent evidence linking childhood NAFLD to CVD and potential pathogenic links.