Nano-hydroxyapatite as a delivery system: overview and advancements. Issue 1 (1st January 2021)

• Record Type: Journal Article
• Authors: Munir, Muhammad Usman; Salman, Sajal; Javed, Ibrahim; Bukhari, Syed Nasir Abbas; Ahmad, Naveed; Shad, Naveed Akhter; Aziz, Farooq
• Is Part Of: Artificial cells, nanomedicine, and biotechnology. Volume 49:Issue 1(2021)
• Page Start: 717
• Page End: 727
• Publication Date: 2021-01-01
• Subjects: Hydroxyapatite -- calcium phosphate -- nanocarrier -- drug delivery systems -- antibiotic -- anticancer; Artificial cells -- Periodicals; Nanotechnology -- Periodicals; Blood substitutes -- Periodicals; Tissue engineering -- Periodicals; Molecules -- Periodicals; Biotechnology -- Periodicals; 615.39
• DOI: 10.1080/21691401.2021.2016785
• Languages: English
• ISSNs: 2169-1401

Abstract

Abstract: Nano-hydroxyapatite is being investigated as vital components of implants and dental and tissue engineering devices. It is found as a bone replacement due to its non-toxicity and cytocompatibility with dental tissues and bone. The reality that nanocrystalline hydroxyapatite can be made of porous granules and scaffolds. Additionally, it has a massive loading potential indicating its use as a transporter for drugs or a regulated drug release mechanism in pharmaceutical research. This review aims to present existing nano-hydroxyapatite research developments as a drug carrier employed in bone tissue disorders locally and deliver poorly soluble drugs with reduced bioavailability. We have discussed the nano-hydroxyapatite role in the delivery of drugs (i.e. anti-resorptive, anti-cancer, and antibiotics), proteins, genetic material, and radionuclides.