A new α-pyrone derivative from Annulohypoxylon stygium SWUF09-030. Issue 12 (2nd December 2021)

• Record Type: Journal Article
• Authors: Pimjuk, Preeyanuch; Mongkolthanaruk, Wiyada; Suwannasai, Nuttika; Senawong, Thanaset; Tontapha, Sarawut; Amornkitbumrung, Vittaya; McCloskey, Sirirath
• Is Part Of: Journal of Asian natural products research. Volume 23:Issue 12(2021)
• Page Start: 1182
• Page End: 1188
• Publication Date: 2021-12-02
• Subjects: Annulohypoxylon -- A. stygium -- α-pyrone -- phenolic -- diketopiperazine; Materia medica -- Asia -- Periodicals; Pharmacognosy -- Asia -- Periodicals; Medicinal plants -- Asia -- Periodicals; Medicine, Oriental -- Asia -- Periodicals; 615.321095
• DOI: 10.1080/10286020.2020.1856095
• Languages: English
• ISSNs: 1028-6020

Abstract

Abstract: A new α-pyrone derivative, namely annulopyronoate (1 ), together with the known isobenzofuranone, diphenyl ether, sesquiterpene, phenolic and diketopiperazine derivatives (2 –12 ) were isolated from a filamentous fungus Annulohypoxylon stygium SWUF09-030. The structures were determined by analysis of spectroscopic and MS data. The absolute configuration of 1 was determined by comparison of experimental and calculated Electronic Circular Dichroism (ECD) spectra. Compounds 3 –5 and 7 exhibited both anti-proliferative effects against HeLa, HT29, HCT116, MCF-7 and Vero cell lines and inhibition of nitric oxide (NO) production in lipopolysaccharide (LPS)-stimulated RAW264.7 macrophage cells. Graphical abstract: UF0001