THU0628 Differences in clinical manifestations of behcet's syndrome by gender: cross-sectional analysis in a uk cohort. (12th June 2018)

• Record Type: Journal Article
• Authors: Chadwick, L.; Blake, T.; Goodson, N.J.; Situnayake, D.; Moots, R.J.
• Is Part Of: Annals of the rheumatic diseases. Volume 77(2018)Supplement 2
• Page Start: 510
• Page End: 510
• Publication Date: 2018-06-12
• Subjects: Rheumatism -- Periodicals; 616.723005
• DOI: 10.1136/annrheumdis-2018-eular.3249
• Languages: English
• ISSNs: 0003-4967

Abstract

Abstract : Background: Geographical variations in genotype and phenotype of Behçet's syndrome (BS) are reported. 1, 2 Previous meta-analysis of international cohorts has highlighted differences in clinical manifestations of BS by gender. 3 A comparison of BS clinical manifestations by gender has not been analysed previously in a large UK BS cohort. Objectives: 1) To compare the clinical manifestations of BS in a UK cohort by gender and 2) to compare this to published international data. Methods: A retrospective cross sectional analysis was performed using clinical databases at the Liverpool and Birmingham BS Centres of Excellence. Patients with a multi-disciplinary diagnosis of BS or International Study Group (ISG) diagnostic criteria were included. Clinical manifestations and HLA-B51 positivity were compared by gender. T-tests and chi-squared tests were used for continuous and categorical data respectively and a p value of 0.05 or less was considered statistically significant. Results: 433 patients met inclusion criteria (140 males, 32.3%). Male patients were younger and had significantly higher rates of ocular and vascular involvement, papulopustular skin rash and HLA-B51 positivity. Female patients had significantly higher rates of genital aphthosis and arthralgia. Conclusions: Similar to published international cohorts, male patients with BS in the UK have higher rates of ocular and venous involvement, papulopustular skin rash and HLA-B51 positivity and lower rates of genital aphthosis and arthralgia in comparison to female patients. However, the extent to which these differences are attributable to ethnicity is unclear. References: [1] Leonardo NM, McNeil J. Behcet's Disease: Is There Geographical Variation? A Review Far from the Silk Road. Int J Rheumatol2015: 1–7. doi:10.1155/2015/945262 [2] Sibley C, Yazici Y, Tascilar K, Khan N, Bata Y, Yazici H, et al. Behçet syndrome manifestations and activity in the United States versus Turkey - a cross-sectional cohort comparison. J Rheumatol2014;41:137984. doi:10.3899/jrheum.131227 [3] Bonitsis NG, Nguyen LBL, LaValley MP, Papoutsis N, Altenburg A, et al. Gender-specific differences in Adamantiades-Behçet's disease manifestations: an analysis of the German registry and meta-analysis of data from the literature. Rheumatology (Oxford). 2015;54: 121–33. doi:10.1093/rheumatology/keu247 Disclosure of Interest: None declared