Localized and Surface Plasmons Coupling for Ultrasensitive Dopamine Detection by means of SPR‐Based Perylene Bisimide/Au Nanostructures Thin Film. Issue 20 (29th September 2021)

• Record Type: Journal Article
• Authors: Pagano, Rosanna; Syrgiannis, Zois; Bettini, Simona; Ingrosso, Chiara; Valli, Ludovico; Giancane, Gabriele; Prato, Maurizio
• Is Part Of: Advanced materials interfaces. Volume 8:Issue 20(2021)
• Page Start: n/a
• Page End: n/a
• Publication Date: 2021-09-29
• Subjects: dopamine -- gold nanostructures -- perylene bisimide derivative -- surface enhanced Raman spectroscopy -- surface plasmon resonance; Materials science -- Periodicals; 620.11
• DOI: 10.1002/admi.202101023
• Languages: English
• ISSNs: 2196-7350

Abstract

Abstract: Dopamine (DA) is an important catecholamine neurotransmitter involved in neural and hormonal functions. Neural diseases, as Parkinson's, are connected to a significant lowering of DA concentration to picomolar levels in cerebrospinal fluid. So, in this contribution, a hybrid active layer based on a perylene bisimide (PBI) derivative and multishaped Au nanostructures is proposed for the development of surface plasmon resonance (SPR) dopamine detection system. PBI molecules, transferred as thin film by the dip coating approach, are demonstrated to be able to detect dopamine down to 10 –12 m by SPR method. The presence of Au nanostructures promotes an important surface enhanced Raman scattering effect of Raman PBI signals highlighting a strong energetic communication between the two species. In this way, when PBI/Au nanostructures (AuNS) films are deposited by the layer‐by‐layer method and used for DA SPR detection, the sensitivity toward dopamine 10 −12 m is doubled. The PBI/AuNS hybrid layer is able to detect picomolar concentration of dopamine, due to the coupling of localized (AuNS) and propagating surface plasmons on SPR slide. In particular, an interfacial coupling among localized surface plasmon resonance on AuNS and the propagating plasmon on Au thin film (of SPR slide) can be promoted. Abstract : A perylene bisimide derivative is used for the implementation of a surface plasmon resonance (SPR) sensing system for dopamine. The coupling of localized and propagating surface plasmons allows dopamine detection in artificial cerebrospinal fluid down to 10 −12 m concentration through immobilization of perylene bisimide/Au nanostructures multilayered film directly onto the SPR slide by means of a modified layer‐by‐layer approach.