Engineering interventions in industrial filamentous fungal cell factories for biomass valorization. (January 2022)

• Record Type: Journal Article
• Authors: Madhavan, Aravind; Arun, KB; Sindhu, Raveendran; Alphonsa Jose, Anju; Pugazhendhi, Arivalagan; Binod, Parameswaran; Sirohi, Ranjna; Reshmy, R.; Kumar Awasthi, Mukesh
• Is Part Of: Bioresource technology. Volume 344:Part A(2022)
• Publication Date: 2022-01
• Subjects: Filamentous fungi -- Genetic engineering -- Recombinant proteins -- Expression host -- Cell factory -- Bulk chemicals; Biomass -- Periodicals; Biomass energy -- Periodicals; Bioremediation -- Periodicals; Agricultural wastes -- Periodicals; Factory and trade waste -- Periodicals; Organic wastes -- Periodicals; Bioénergie -- Périodiques; Déchets agricoles -- Périodiques; Déchets industriels -- Périodiques; Déchets organiques -- Périodiques; Déchets (Combustible) -- Périodiques; 662.88
• DOI: 10.1016/j.biortech.2021.126209
• Languages: English
• ISSNs: 0960-8524

Abstract

Highlights: Fungal cell factories for fuels and chemicals. Engineering strategies for efficient enzyme secretion for lignocellulose hydrolysis. Transcription regulator engineering for enhancing lignocellulose degradation. Abstract: Filamentous fungi possess versatile capabilities for synthesizing a variety of valuable bio compounds, including enzymes, organic acids and small molecule secondary metabolites. The advancements of genetic and metabolic engineering techniques and the availability of sequenced genomes discovered their potential as expression hosts for recombinant protein production. Remarkably, plant-biomass degrading filamentous fungi show the unique capability to decompose lignocellulose, an extremely recalcitrant biopolymer. The basic biochemical approaches have motivated several industrial processes for lignocellulose biomass valorisation into fermentable sugars and other biochemical for biofuels, biomolecules, and biomaterials. The review gives insight into current trends in engineering filamentous fungi for enzymes, fuels, and chemicals from lignocellulose biomass. This review describes the variety of enzymes and compounds that filamentous fungi produce, engineering of filamentous fungi for biomass valorisation with a special focus on lignocellulolytic enzymes and other bulk chemicals.