THU0384 Salivary gland ultrasonography and stimulated salivary flow correlated with salivary gland biopsy among patients with sjÖgren syndrome and sicca symptoms: experience from a single medical centre in taiwan. (12th June 2018)

• Record Type: Journal Article
• Authors: Tsao, Y.P.; Chen, M.H.; Wu, S.Y.; Wu, C.Y.; Chen, W.S.; Lai, C.C.; Tsai, C.Y.
• Is Part Of: Annals of the rheumatic diseases. Volume 77(2018)Supplement 2
• Page Start: 407
• Page End: 407
• Publication Date: 2018-06-12
• Subjects: Rheumatism -- Periodicals; 616.723005
• DOI: 10.1136/annrheumdis-2018-eular.6445
• Languages: English
• ISSNs: 0003-4967

Abstract

Abstract : Background: Sjögren's syndrome is an autoimmune disease that involves several organs. In the latest classification criteria, salivary minor gland is one of the major factor contributing to the diagnosis. Ultrasonography is a non-invasive, easy accessible tool in evaluation the contour and structure of salivary glands, which have been shown to have efficacy in monitoring the disease status of Sjögren's syndrome as well as in diagnosis the disease. Otherwise, salivary flow rate is another component of classification criteria, and its association with disease activity remains to be elucidated. Objectives: To investigate the efficacy of salivary gland ultrasonography and salivary flow rate in patients with Sjögren's syndrome and Sicca symptoms. Methods: Total 97 patients of primary or secondary Sjögren's syndrome, and patients with sicca symptoms were enrolled. Ultrasonography was performed at parotid and submandibular glands with 13–16MHz linear probe. Each gland was scored from 0 to 4. Minor salivary gland biopsy results were examined by pathologist with Chisholm-Mason grade. Unstimulated salivary flow rate was recorded first, and stimulated salivary flow rate was tested after 5 min of sugar-free chewing gum stimulation. Patients' symptoms were recorded by ESSPRI questionnaires. Results: Total 56 primary Sjögren's Syndrome, 10 secondary Sjögren's Syndrome, and 31 patients with sicca symptoms were enrolled. Significant correlations were noted between unstimulated salivary flow rate and minor gland biopsy (p=0.029), stimulated salivary flow rate and biopsy (p=0.006), salivary gland ultrasonography and minor gland biopsy (p<0.001), and minor gland biopsy with serum anti-SSB (La) level (p=0.009). The correlations between minor gland biopsy and serum anti-SSA (Ro) level was not significant. The stimulated salivary flow rate also correlated with self-reported dryness in ESSPRI questionnaires (p=0.018). The salivary gland ultrasonography also correlated with ESSPRI (p<0.001) and the three factors in ESSPRI (dryness, p<0.001; pain, p=0.039; fatigue, p=0.002). Conclusions: Both salivary gland ultrasonography and salivary flow rate correlated with the severity of salivary minor gland biopsy. The stimulated salivary flow rate had better correlations with the biopsy result than unstimulated flow, and it also correlated with patients' self-reported dryness symptoms. Salivary gland ultrasonography had correlations with symptoms of patient. These non-invasive methods may play roles in evaluation of the disease activity. Disclosure of Interest: None declared