Microbubble Functionalization with Platelet Membrane Enables Targeting and Early Detection of Sepsis‐Induced Acute Kidney Injury. Issue 23 (12th September 2021)

• Record Type: Journal Article
• Authors: Yang, Jing; Miao, Xiaoyan; Guan, Yu; Chen, Chaojin; Chen, Sufang; Zhang, Xinmin; Xiao, Xue; Zhang, Zheng; Xia, Zhengyuan; Yin, Tinghui; Hei, Ziqing; Yao, Weifeng
• Is Part Of: Advanced healthcare materials. Volume 10:Issue 23(2021)
• Page Start: n/a
• Page End: n/a
• Publication Date: 2021-09-12
• Subjects: acute kidney injury -- microbubbles -- molecular ultrasound imaging -- platelet membranes -- sepsis; Biomedical materials -- Periodicals; 610.28
• DOI: 10.1002/adhm.202101628
• Languages: English
• ISSNs: 2192-2640

Abstract

Abstract: The morbidity and mortality of sepsis‐induced acute kidney injury (SAKI) remain high. Early detection using molecular ultrasound imaging may reduce mortality and improve the prognosis. Inspired by the intrinsic relationship between platelets and SAKI, platelet membrane‐coated hybrid microbubbles (Pla‐MBs) are designed for early recognition of SAKI. Pla‐MBs are prepared by ultrasound‐assisted recombination of liposomes and platelets, consisting of inherent platelet membrane isolated from platelets. By coating with platelet membranes, Pla‐MBs are endowed with various adhesive receptors (such as integrin α IIb β 3), providing a benefit for selective adhesion to damaged endothelium in SAKI. In a rat SAKI model, by combining the advantages of molecular ultrasound imaging and platelet membrane, Pla‐MBs display platelet‐mimicking properties and achieve the early targeted diagnosis of SAKI prior to the regular laboratory markers of kidney function. Moreover, the expression of platelet‐binding proteins (von Willebrand factor and fibrinogen) in the kidneys shows consistent results with molecular ultrasound imaging. Together, microbubble functionalization with platelet membranes is diagnostically beneficial for SAKI and might be a promising modality for endothelial injury diseases in the future. Abstract : Platelet membrane‐coated hybrid microbubbles (Pla‐MBs) are established by ultrasound‐assisted recombination of liposomes and platelet membranes to selectively bind to damaged endothelium. Based on molecular ultrasound imaging and various adhesive receptors (such as integrin α IIb β 3) of platelet membranes, Pla‐MBs display platelet‐mimicking properties and achieve early targeted diagnosis of sepsis‐induced acute kidney injury prior to the regular laboratory markers of kidney function.