DTBP‐Mediated Cascade Spirocyclization and Dearomatization of Biaryl Ynones: Facile Access to Spiro[5.5]trienones through C(sp3)−H Bond Functionalization. Issue 31 (17th August 2021)

• Record Type: Journal Article
• Authors: Zhang, Ming‐Ming; Shen, Liu‐Yu; Dong, Sa; Li, Bing; Meng, Fei; Si, Wei‐Jie; Yang, Wen‐Chao
• Is Part Of: European journal of organic chemistry. Issue 31(2021)
• Page Start: 4465
• Page End: 4468
• Publication Date: 2021-08-17
• Subjects: Alkynes -- C(sp3)−H bonds -- Dearomatization -- Ketones -- Radical reaction; Chemistry, Organic -- Periodicals; Organic compounds -- Synthesis -- Periodicals; Bioorganic chemistry -- Periodicals; Chemistry, Physical organic -- Periodicals; 547
• DOI: 10.1002/ejoc.202100656
• Languages: English
• ISSNs: 1434-193X

Abstract

Abstract: Oxidative radical cascade spirocyclization and dearomatization of biary ynones with a variety of hydrocarbons including toluenes, ethers, ketones, and alkanes has been developed to construct alkyl substituted spiro[5.5]trienones. Abstract : A novel DTBP‐promoted metal‐free cascade cyclization of biary ynones with a variety of hydrocarbons including toluenes, ethers, ketones and alkanes has been established, which provides an expeditious approach to access functionalized spiro[5.5]trienones in moderate to good yields. The products thus obtained represent key structural motifs of biologically active molecules in pesticide.