Amplifying elements of arthritis and joint destruction. (12th October 2007)

• Record Type: Journal Article
• Authors: van den Berg, Wim B; van Lent, Peter L; Joosten, Leo A B; Abdollahi-Roodsaz, Shahla; Koenders, Marije I
• Is Part Of: Annals of the rheumatic diseases. Volume 66(2007)Supplement 3
• Page Start: iii45
• Page End: iii48
• Publication Date: 2007-10-12
• Subjects: Rheumatism -- Periodicals; 616.723005
• DOI: 10.1136/ard.2007.079830
• Languages: English
• ISSNs: 0003-4967

Abstract

Abstract : Rheumatoid arthritis (RA) is a systemic autoimmune disease characterised by chronic joint inflammation and variable degrees of bone and cartilage erosion. Studies in animal models of arthritis provide insight into elements which can amplify destructive features. The presence of immune complexes in the joint makes arthritis more erosive. Although considerable bone erosion still occurs in the absence of FcγR triggering by immune complexes, through cytokine-induced RANKL and direct osteoclast activation, cartilage erosion is heavily dependent on the FcγR pathway. T cell factors such as IFNγ and IL17 further amplify erosion through upregulation of the damaging FcγRI and stimulation of the influx of granulocytes, respectively. Apart from immune elements, environmental pressure and components of tissue damage contribute through innate pathways. Spontaneous T cell-dependent arthritis in IL1Ra–/– mice is absent under germ-free conditions, and markedly suppressed in TLR4-deficient mice. Moreover, TLR4 blocking with a receptor antagonist suppresses erosive arthritis.