AIDS and haemophilia: morbidity and morality in a well defined population. Issue 6497 (14th September 1985)

• Record Type: Journal Article
• Authors: Jones, P; Hamilton, P J; Bird, G; Fearns, M; Oxley, A; Tedder, R; Cheingsong-Popov, R; Codd, A
• Is Part Of: BMJ. Volume 291:Issue 6497(1985)
• Page Start: 695
• Page End: 699
• Publication Date: 1985-09-14
• Subjects: Medicine -- Periodicals; Medicine -- Periodicals; Medicine; Periodicals; 610
• DOI: 10.1136/bmj.291.6497.695
• Languages: English
• ISSNs: 0007-1447

Abstract

Abstract : One hundred and forty-three multitransfused patients with hereditary haemostatic disorders were examined for evidence of disease related to the acquired immune deficiency syndrome (AIDS). Ninety-nine patients with severe haemophilia A were tested for anti-HTLV-III and 76 were found to be positive. All except one of these seropositive patients had received commercial factor VIII concentrates at some time. Eighteen patients with haemophilia B were tested and all were anti-HTLV-III negative. Three out of 36 sexual partners of patients with haemophilia A positive for anti-HTLV-III were also seropositive. One, who had recently received blood transfusions, had AIDS with Pneumocystis carinii pneumonia. Three patients with severe haemophilia A died from Aids. A further 30 haemophiliacs had AIDS related complex or lymphadenopathy that could be related to HTLV-III infection. There was a significant correlation between lymphadenopathy and anti-HTLV-III seropositivity. No evidence of casual spread of AIDS was found since all 68 health care staff tested were anti-HTLV-III negative, including three surgeons who regularly worked with patients positive for anti-HTLV-III. The resources devoted to counselling and laboratory support in centres treating people at risk and their families need to be urgently reassessed.