Sulpiride and the potentiation of progestogen only contraception. Issue 6495 (31st August 1985)

• Record Type: Journal Article
• Authors: Payne, M R; Howie, P W; McNeilly, A S; Cooper, W; Marnie, M; Kidd, L
• Is Part Of: BMJ. Volume 291:Issue 6495(1985)
• Page Start: 559
• Page End: 561
• Publication Date: 1985-08-31
• Subjects: Medicine -- Periodicals; Medicine -- Periodicals; Medicine; Periodicals; 610
• DOI: 10.1136/bmj.291.6495.559
• Languages: English
• ISSNs: 0007-1447

Abstract

Abstract : A progestogen (norethisterone) and a dopamine antagonist (sulpiride) were given alone and in combination to volunteers to examine their effects on excretion of ovarian steroids. Compared with non-treatment cycles (n = 15), contraception with a progestogen alone (n = 10) was associated with increased excretion of oestrone and partial suppression of excretion of pregnanediol, suggesting partial luteinization of unruptured follicles. By contrast, the combination of norethisterone and sulpiride (n = 9) suppressed both ovarian steroids to basal values, the suppression being even greater than with sulpiride alone (n = 5). These results suggest that a combination of a progestogen with a dopamine antagonist might have a role in contraception.