AB0789 How does the duration of the disease influence the quality of life?. (12th June 2018)

• Record Type: Journal Article
• Authors: Loghin-Oprea, N.; Vetrila, S.; Mazur-Nicorici, L.; Salaru, V.; Mazur, M.
• Is Part Of: Annals of the rheumatic diseases. Volume 77(2018)Supplement 2
• Page Start: 1528
• Page End: 1528
• Publication Date: 2018-06-12
• Subjects: Rheumatism -- Periodicals; 616.723005
• DOI: 10.1136/annrheumdis-2018-eular.5450
• Languages: English
• ISSNs: 0003-4967

Abstract

Abstract : Background: It is noticed that over the last decades the prognostic in patients with Idiopathic Inflammatory Myopathies (IIM) – a group of autoimmune disease characterised by muscle involvement, has improved along with increasement of disease duration and thus affects the quality of life. Objectives: To assess the patient's quality of life related to the duration of the disease. Methods: We performed a cross-sectional study from December 2015 to December 2017, the patients included fulfilled the Bohan and Peter 1 criteria for IIM. Demographic and clinical data were collected using a special questionnaire. Consistent with the objective the study group was divided in two subgroups by disease duration 1-less than 24 months and second subgroup maore than 2 years. In order to estimate the quality of life (QoL) was applied Short Form-8 with 8 items for 8 domains and two components: mental and physical. Statistical data was analysed using MedCalc software version 12. Results: There were 67 patients enrolled in the study, including 51 females and 16 males with a F:M ratio of 3.2:1, mean age 53.1±12.5 (range 25–78). The disease mean disease duration was 8.3±5.3 (range 0.5–12) years, there were 16 patients in the subgroup with the disease duration less than 2 years. The mean physical component was 36.48±9.05 and the mental component – 41.69±9.62 points, determined as reduced quality of life. Regarding the QoL of patients from subgroup 1, we found the physical component – 38.15±8.83 and the mental was 40.95±9.22 points. In the second subgroup we appreciated the physical and the mental component – 35.77±9.14 and 42.01±9.86 points, respectively. It was identified moderate correlation (r=0.49 p<0.005) between the both domains of the QoL and disease duration till 2 years, for the duration of more than 2 years we found moderate correlation (r=0.51 p<0.005) with mental compound and a weak one for physical domain (r=0.24 p<0.005). Conclusions: Patients with idiopathic inflammatory myopathies had reduced quality of life by both domains. Disease duration in patients with early idiopathic inflammatory myopathies – less than 2 years, has a greater impact on patient's quality of life. Reference: [1] Bohan A, Peter JB. N Engl J Med1975Feb 13;292(7):344–7. Disclosure of Interest: None declared