Relation between consumption of alcohol and fatty acids esterifying serum cholesterol in healthy men. Issue 6485 (22nd June 1985)

• Record Type: Journal Article
• Authors: Warnet, J M; Cambien, F; Vernier, V; Pecoraro, M; Flament, C; Ducimetiere, P; Jacqueson, A; Richard, J L; Claude, J R
• Is Part Of: BMJ. Volume 290:Issue 6485(1985)
• Page Start: 1859
• Page End: 1861
• Publication Date: 1985-06-22
• Subjects: Medicine -- Periodicals; Medicine -- Periodicals; Medicine; Periodicals; 610
• DOI: 10.1136/bmj.290.6485.1859
• Languages: English
• ISSNs: 0007-1447

Abstract

Abstract : The relation between consumption of alcohol (established by interview), two of its typical markers (gamma-glutamyltransferase activity and mean corpuscular volume), and the composition of fatty acids in plasma cholesterol esters was investigated in an epidemiological study of 1467 actively employed men aged 35-45. In this group of subjects mean consumption of alcohol was 34.6 (SD 25.2) g/day. Palmitoleic acid and oleic acid were positively correlated with consumption of alcohol, gamma-glutamyltransferase activity, and mean corpuscular volume, while linoleic acid was negatively correlated with these variables. When these three fatty acids, gamma-glutamyltransferase activity, mean corpuscular volume, and the fat content of the diet were introduced into a multivariate regression analysis, with consumption of alcohol as the dependent variable, only palmitoleic acid, gamma-glutamyltransferase activity, mean corpuscular volume, and the monounsaturated fat content of the diet remained significant. Palmitoleic acid seems to be an independent correlate of consumption of alcohol and could be useful in epidemiological and clinical studies as a variable of consumption.