Circulating mitochondrial biomarkers for drug-induced liver injury. (November 2015)

• Record Type: Journal Article
• Authors: Shi, Qiang; Yang, Xi; Mattes, William B; Mendrick, Donna L; Harrill, Alison H; Beger, Richard D
• Is Part Of: Biomarkers in medicine. Volume 9:Number 11(2015)
• Page Start: 1215
• Page End: 1223
• Publication Date: 2015-11
• Subjects: acetaminophen -- biomarker -- drug-induced liver injury -- hepatotoxicity -- mitochondrion; Biochemical markers -- Periodicals; 610.28
• DOI: 10.2217/bmm.15.59
• Languages: English
• ISSNs: 1752-0363

Abstract

Liver mitochondria affected by drugs can be released into circulation and serve as biomarkers for drug-induced liver injury (DILI). The tissue specificity of ALT was improved by differentiating cytosolic ALT1 and mitochondrial ALT2 isoforms released in circulation. Prior to ALT elevation, mitochondrial cytochrome c, OCT, GLDH, CPS1 and DNA were increased in circulation following DILI. The baseline expression of mt-Nd6 was predictive of individual DILI susceptibility in animals. As mitochondrial DILI biomarkers appeared to be drug or species dependent, they might have value in clinical scenarios when culprit drugs are established, but may not be ideal tools to assess DILI potentials of new drugs.