Revisiting the relationship between neural correlates of sensory gating and self-reported sensory gating inventory: An MEG investigation. (1st January 2022)

• Record Type: Journal Article
• Authors: Jian, Jun-Rui; Lin, Yen-Yun; Connor, Lisa Tabor; Cheng, Chia-Hsiung
• Is Part Of: Neuroscience letters. Volume 766(2022)
• Publication Date: 2022-01-01
• Subjects: Sensory gating (SG) -- Sensory Gating Inventory (SGI) -- Hemispheric asymmetry -- Magnetoencephalography (MEG) -- Frontal cortex; Neurology -- Periodicals; Neurology -- Periodicals; Research -- Periodicals; Neurologie -- Périodiques; Neuroanatomie -- Périodiques; Neuropharmacologie -- Périodiques; Neurophysiologie -- Périodiques; Neurology; Periodicals; Electronic journals; 617.48
• DOI: 10.1016/j.neulet.2021.136336
• Languages: English
• ISSNs: 0304-3940

Abstract

Highlights: We use MEG to study associations between cortical SG function and scores on SGI. SG of right inferior frontal gyrus is correlated with perceptual modulation of SGI. We suggest SG is an objective reflection of self-reported perceptual disturbance. Abstract: Background: Accumulated evidence has revealed that bilateral superior temporal gyrus (STG), inferior frontal gyrus (IFG), and inferior parietal lobule (IPL) are involved in the processes of sensory gating (SG). However, it remains unknown which neural correlate(s) of SG specifically reflect individuals' perceptual experiences, as measured by the Sensory Gating Inventory (SGI). Thus, this study aims to investigate the relationship of SGI with cortical SG-related regions. Furthermore, we examine whether SG hemispheric asymmetry exists, which is still an inconclusive issue. Methods: Twenty-two healthy young adults performed the auditory paired-stimulus paradigm during magnetoencephalographic recordings. SG of M50 and M100 was measured as ratios (S2/S1) and differences (S1–S2). They were also evaluated with SGI, which factored into three categories of Perceptual Modulation, Distractibility, and Over-Inclusion. SG in the STG, IFG, and IPL were compared between left and right hemispheres, and were used to determine the relationship with SGI. Results: Only M100 SG differences (S1–S2) of the right IFG were significantly correlated with scores of Perceptual Modulation (partial r = -0.392, p = 0.040) and total SGI scores (partial r = -0.387, p = 0.041). However, we did not find significant lateralization of M50 SG and M100 SG in any studying region. Conclusions: The individual's perceptual experience is specifically related to electrophysiological SG function of the right IFG.