AB0895 Are lateral spine bone mineral density measurements useful in axial spondyloarthritis?. (12th June 2018)

• Record Type: Journal Article
• Authors: Hamdi, W.; Ben Nessib, D.; Riahi, H.; Kasraoui, A.; Maatallah, K.; Kaffel, M.D.; Bouaziz, M.; Ladeb, M.F.; Kchir, M.M.
• Is Part Of: Annals of the rheumatic diseases. Volume 77(2018)Supplement 2
• Page Start: 1572
• Page End: 1572
• Publication Date: 2018-06-12
• Subjects: Rheumatism -- Periodicals; 616.723005
• DOI: 10.1136/annrheumdis-2018-eular.5397
• Languages: English
• ISSNs: 0003-4967

Abstract

Abstract : Background: Bone loss leading to osteoporosis (OP) is a well-known feature of axial spondyloarthritis (AS) although this disease is characterised by calcification in extra osseous tissues and new bone formation. In fact, dual-energy X-ray absorptiometry (DEXA) is the most common imaging method used to measure the bone mineral density (BMD). However, many studies have shown an inferiority of the postero-anterior (PA) spine measurements in reflecting the bone loss compared to lateral spine measurements because of the bridging syndesmophytes which may overestimate the BMD. Objectives: Our aim is to evaluate the Lateral spine BMD (L-BMD) in AS and to assess its association with the disease features. Methods: Seventy-five patients who met the Modified New York Classification criteria for AS were enrolled in this cross-sectional study. BMD was measured using DEXA at PA lumbar, lateral lumbar and hip regions. Results: Sixty-two men and 13 women were enrolled with an average age of 36.8±11.8 years. Bone loss (osteopenia or OP) was noted in 65% of the patients (n=46) in PA lumbar and in 63% in lateral lumber (n=45). In L-BMD, BMD was correlated with early menopause and vitamin D level (p=0.01 and p=0.04 respectively). T-score in lateral spine was correlated with coffee consumption (p=0.02), physical inactivity (p=0.037), sexual hormones disorders (p=0.02), hip arthritis (p=0.017), BASMI (p=0.001), BASFI (p=0.03) and ASDASVS (p=0.03) scores, ESR (p=0.003) and CRP (p=0.03) levels, and hip (p=0.004), spine (p=0.007) and total (p=0.001) BASRI. Conclusions: L-BMD seems to be a reliable measurement in AS, and may avoid the overestimation of the BMD values and allows consequently to detect spinal osteoporosis and prevent fractures in AS. References: [1] El Maghraou A, Borderie D, Cherruau B, Edouard R, Roux C, Dougados M (1999) Osteoporosis, body composition, and bone turnover in ankylosing spondylitis. J Rheumatol26:2205–2209 [2] Mitra D, Elvins DM, Speden DJ, Collins AJ (2000) The prevalence of vertebral fractures in mild ankylosing spondylitis and their relationship to bone mineral density. Rheumatology39:85–89 Disclosure of Interest: None declared