THU0173 Trends in hip fracture incidence in rheumatoid arthritis: a national observatinal cohort study. (12th June 2018)

• Record Type: Journal Article
• Authors: Mazzucchelli, R.; Perez-Fernandez, E.; Crespí, N.; Quirós, J.; Macía Villa, C.; Espinosa, M.; Morell Hita, J.L.; Peña, M.; Villaverde, V.; Martinez-Prada, C.; Morado Quiroga, C.; Barbadillo, C.; Fernández-Prada, M.; Godoy, H.; Galindo, M.; García-Vadillo, A.; Guzón Illescas, O.; Herranz, A.
• Is Part Of: Annals of the rheumatic diseases. Volume 77(2018)Supplement 2
• Page Start: 305
• Page End: 305
• Publication Date: 2018-06-12
• Subjects: Rheumatism -- Periodicals; 616.723005
• DOI: 10.1136/annrheumdis-2018-eular.1206
• Languages: English
• ISSNs: 0003-4967

Abstract

Abstract : Background: During the last 20 years there have been significant changes in the treatment of patients with rheumatoid arthritis (RA) and in the prevention and treatment of osteoporosis. The potential impact of these strategies on important outcomes as the incidence of hip fracture in RA is unknown. Objectives: To analyse the incidence and trend of hospital admissions for hip fracture in patients with RA, in Spain, during the period between 1999 and 2015. Methods: This is a retrospective population based study. We analysed a national administrative database that includes a Minimum Basic Data Set (MBDS) of hospital admissions of patients with RA. Period: 1999 to 2015. The hip fracture cases were identified by the presence in primary and secondary diagnosis of ICD 9 codes. The population at risk was estimated through the population census of the National Institute of Statistics, with an estimated prevalence of RA of 0.5%. The crude and adjusted rates of hip fracture were calculated. The trend was analysed using Generalised Linear Models (GLM) using the year variable as the analysis variable. Results: Of a total of 338.343 admissions of patients with RA, 6.656 (2%) was due to hip fracture, 5.608 (84.2%) in women and 1.048 (15.7%) in men. The mean age was 77.54 (SD 9.6). Mean age increased linearly during the study period (from 75, 3 years in 1999 to 79, 9 in 2015). There was a total of 326 (4.9%) deaths during admission. The fracture age-adjusted rate during the study period was 243, 66/100.000 RA-patients*year (245, 24 in women and 198, 05 in men). The fracture age-adjusted rate increased from 150.11/100.000*year in 1999, to 303.12 in 2015 (in both sex). In women from 134.71 in 1999 to 304.83 in 2015) and in men from 99.63 in 1999 to 268.5 in 2015). An annual increase in the fracture rate of 3.1% is estimated. Conclusions: In Spain, during the period from 1999 to 2015, although the mean age has increased, the incidence of hip fracture has not been reduced. We estimate an annual increase of 3.1%. Disclosure of Interest: None declared