AB0638 Clinical significance of esr in chinese patients with systemic lupus erythematosus. (12th June 2018)

• Record Type: Journal Article
• Authors: Xu, Y.; Feng, X.; Sun, L.
• Is Part Of: Annals of the rheumatic diseases. Volume 77(2018)Supplement 2
• Page Start: 1466
• Page End: 1466
• Publication Date: 2018-06-12
• Subjects: Rheumatism -- Periodicals; 616.723005
• DOI: 10.1136/annrheumdis-2018-eular.3378
• Languages: English
• ISSNs: 0003-4967

Abstract

Abstract : Background: During the process of systemic lupus erythematosus (SLE), disease flare and infection are often accompanied by each other and always pose a major challenge to clinical treatments. Although erythrocyte sedimentation rate (ESR) has been tested in SLE patients for many years, there is still a lack of consensus on its value. Objectives: To validate the value of ESR in Chinese SLE patients at the time of their first admission and to determine whether it is related to a poor outcome. Methods: Clinical data of patients with ESR tested on their first admission were extracted from our SLE database; (Feng et al. PLoS ONE 2016;11(12): e0168619) and analysed for the relation with disease activity (SLEDAI), infection status, organ involvements and survival situation. To determine the risk of ESR for long-term mortality, cumulative survival was illustrated with the Kaplan-Meier plot and factors were compared using the Log-rank test. Results: Totally 1225 patients were included in this study, of which 92.2% were female and the median age at admission was 34.3 years. The most often seen organ involvements were mucocutaneous (66.4%), musculoskeletal (55.0%), renal (51.7%) and hematologic (45.2%) respectively. ESR levels were correlated with SLEDAI scores (r=0.145, p=0.000), but not elevated in patients with infections. Patients with cardiopulmonary, renal or hematologic impairments had higher ESR levels (all p<0.05). Subgroup analysis showed that serositis, renal insufficiency and anaemia might be responsible for the respective organ involvement. The ten year survival rates for patients with elevated ESR was 80.57%, lower that of 88.62% for patients with normal ESR (p<0.01) (figure 1). Conclusions: High ESR levels in SLE patients are associated with active disease and specific organ involvements, and may predict a poor prognosis. It should be checked routinely for the monitoring of SLE patients. Disclosure of Interest: None declared