IL-18: The Forgotten Cytokine in Dengue Immunopathogenesis. (19th November 2021)

• Record Type: Journal Article
• Authors: Nanda, Josephine Diony; Ho, Tzong-Shiann; Satria, Rahmat Dani; Jhan, Ming-Kai; Wang, Yung-Ting; Lin, Chiou-Feng
• Other Names: Domingues Passero Luiz Felipe Academic Editor.
• Is Part Of: Journal of immunology research. Volume 2021(2021)
• Publication Date: 2021-11-19
• Subjects: Immunology -- Periodicals; Immunology -- Research -- Periodicals; 616.07905
• DOI: 10.1155/2021/8214656
• Languages: English
• ISSNs: 2314-8861

Abstract

Abstract : Dengue fever is an infection by the dengue virus (DENV) transmitted by vector mosquitoes. It causes many infections in tropical and subtropical countries every year, thus posing a severe disease threat. Cytokine storms, one condition where many proinflammatory cytokines are mass-produced, might lead to cellular dysfunction in tissue/organ failures and often facilitate severe dengue disease in patients. Interleukin- (IL-) 18, similar to IL-1 β, is a proinflammatory cytokine produced during inflammation following inflammasome activation. Inflammatory stimuli, including microbial infections, damage signals, and cytokines, all induce the production of IL-18. High serum IL-18 is remarkably correlated with severely ill dengue patients; however, its possible roles have been less explored. Based on the clinical and basic findings, this review discusses the potential immunopathogenic role of IL-18 when it participates in DENV infection and dengue disease progression based on existing findings and related past studies.