Comparative Analysis of the Effects of the Anti-VEGF Drug and Glucocorticoid by Injection before the End of Vitrectomy for Proliferative Diabetic Retinopathy. (21st October 2021)

• Record Type: Journal Article
• Authors: Zhao, Haijin; Li, Xueling; Zhao, Xiahai; Zhang, Qiongfang; He, Wei; Wei, Yanfei; Tang, Xueshan
• Other Names: Tan Songwen Academic Editor.
• Is Part Of: Evidence-based complementary and alternative medicine. Volume 2021(2021)
• Publication Date: 2021-10-21
• Subjects: Alternative medicine -- Periodicals; 615.505
• DOI: 10.1155/2021/1285372
• Languages: English
• ISSNs: 1741-427X

Abstract

Abstract : Objective . To explore the effects of the anti-VEGF drug and glucocorticoid by injection before the end of vitrectomy for proliferative diabetic retinopathy (PDR). Methods . Eighty PDR patients who underwent vitrectomy in our hospital (July 2020–June 2022) were selected as the research objects and randomized into group A ( n = 40) and group B ( n = 40) according to the order of admission. Before the end of surgery, group B was injected with glucocorticoid (triamcinolone acetonide) into the vitreous cavity, and group A was injected with anti-VEGF drug (conbercept). The ophthalmic parameters, incidence of complications, diabetes indexes, and surgical indexes of the two groups were compared. Results . The best corrected visual acuity (BCVA), central macular thickness (CMT), macular blood flow density and intraocular pressure in group A were remarkably better than those in group B (P < 0.001 ). The incidence of complications (P < 0.05 ) and VEG/F level (P < 0.001 ) in group A were obviously lower than those in group B. There was no significant difference in fasting blood glucose (FBG) and surgical indexes between the two groups (P > 0.05 ). Conclusion . Conbercept injection before the end of vitrectomy can improve the ophthalmic parameters, reduce the level of VEGF, and lower the possibility of postsurgical complications. Therefore, the low-cost and efficient anti-VEGF drug should be promoted and applied in practice.