Cisplatin-induced syndrome of inappropriate antidiuretic hormone secretion (SIADH) with life-threatening hyponatraemia. (31st January 2018)

• Record Type: Journal Article
• Authors: Tan, Aaron C.; Marx, Gavin M.
• Is Part Of: BMJ case reports. Volume 2018
• Publication Date: 2018-01-31
• Subjects: chemotherapy -- urological cancer -- unwanted effects / adverse reactions; Medicine -- Case studies -- Periodicals; 610.5
• DOI: 10.1136/bcr-2017-222948
• Languages: English
• ISSNs: 1757-790X

Abstract

Abstract : We present a case of cisplatin-induced syndrome of inappropriate antidiuretic hormone (SIADH) in a patient with metastatic recurrent urothelial carcinoma. Cisplatin-induced SIADH is an uncommon but potentially life-threatening toxicity. Pharmacogenetic characteristics may result in different toxicity profiles in different populations. With such widespread use of cisplatin in a diverse range of cancers, prompt recognition is crucial to detect and prevent severe neurological sequelae.