P268 Is bronchiectasis severity influenced by aetiology or co-morbid airways disease?. (15th November 2016)

• Record Type: Journal Article
• Authors: Quinn, TM; Hill, AT
• Is Part Of: Thorax. Volume 71(2016)Supplement 3
• Page Start: A233
• Page End: A233
• Publication Date: 2016-11-15
• Subjects: Chest -- Diseases -- Periodicals; Thorax; Chest -- Diseases; Periodicals; Periodicals; 617.54
• DOI: 10.1136/thoraxjnl-2016-209333.411
• Languages: English
• ISSNs: 0040-6376

Abstract

Abstract : Background: There is increased interest whether aetiology and co-morbid airways disease influence bronchiectasis disease severity. Methods: We conducted a retrospective study of 400 patients attending a specialist bronchiectasis clinic in NHS Lothian, Edinburgh, UK between May 2013 and September 2014 and using multivariable models we identified independent risk factors that influenced bronchiectasis disease severity using the Bronchiectasis Severity Index. We adjusted for age, sex, smoking history, aetiology and presence of co-morbid airways disease (asthma and COPD). Results: 400 patients were included in this study. The mean age was 66.0 (13.9) years. 253 (63.2%) were female. The majority (77%) had idiopathic (53%) or post infective bronchiectasis (24%). Other aetiologies were: allergic bronchopulmonary aspergillosis 8%; immune/auto-immune 6%; interstitial lung disease 3%; ciliary defects 3%; and inflammatory bowel disease 3%. Co-existing airways disease was common but not the predominant diagnosis (36% had asthma and 19% COPD). Independent risk factors for severe bronchiectasis (BSI ≥ 9) were age 70–79 (OR 6.3, p = 0.003), age 80 and above (OR 7.3, p = 0.003) and smoking (OR 1.02, p = 0.002). It was not influenced by presence of airways disease or aetiology. Conclusion: In conclusion, neither aetiology nor presence of airways disease was independent risk factors for severe bronchiectasis severity. Age was the strongest independent predictor for severe bronchiectasis severity.