A review of magnetoencephalography use in pediatric epilepsy: an update on best practice. (2nd November 2021)

• Record Type: Journal Article
• Authors: Otsubo, Hiroshi; Ogawa, Hiroshi; Pang, Elizabeth; Wong, Simeon M; Ibrahim, George M; Widjaja, Elysa
• Is Part Of: Expert review of neurotherapeutics. Volume 21:Number 11(2021)
• Page Start: 1225
• Page End: 1240
• Publication Date: 2021-11-02
• Subjects: Drug-resistant epilepsy -- magnetoencephalography -- epileptogenic zone -- eloquent cortex mapping -- epilepsy surgery evaluation; Neuropharmacology -- Periodicals; 615.7805
• DOI: 10.1080/14737175.2021.1910024
• Languages: English
• ISSNs: 1473-7175

Abstract

ABSTRACT: Introduction : Magnetoencephalography (MEG) is a noninvasive technique that is used for presurgical evaluation of children with drug-resistant epilepsy (DRE). Areas covered : The contributions of MEG for localizing the epileptogenic zone are discussed, in particular in extra-temporal lobe epilepsy and focal cortical dysplasia, which are common in children, as well as in difficult to localize epilepsy such as operculo-insular epilepsy. Further, the authors review current evidence on MEG for mapping eloquent cortex, its performance, application in clinical practice, and potential challenges. Expert opinion : MEG could change the clinical management of children with DRE by directing placement of intracranial electrodes thereby enhancing their yield. With improved identification of a circumscribed epileptogenic zone, MEG could render more patients as suitable candidates for epilepsy surgery and increase utilization of surgery.