FRI0559 Biomechanical properties of radial bone are different between auto-antibody positive and negative rheumatoid arthritis. (12th June 2018)

• Record Type: Journal Article
• Authors: Stemmler, F.; Simon, D.; Liphardt, A.-M.; Englbrecht, M.; Rech, J.; Hueber, A.; Engelke, K.; Schett, G.; Kleyer, A.
• Is Part Of: Annals of the rheumatic diseases. Volume 77(2018)Supplement 2
• Page Start: 804
• Page End: 804
• Publication Date: 2018-06-12
• Subjects: Rheumatism -- Periodicals; 616.723005
• DOI: 10.1136/annrheumdis-2018-eular.3757
• Languages: English
• ISSNs: 0003-4967

Abstract

Abstract : Background: Functional properties of bone in rheumatoid arthritis (RA) are still not well characterised. Objectives: This study aimed to define the impact of anti-citrullinated antibodies (ACPA) on biomechanical properties in RA. Methods: Based on on high-resolution peripheral quantitative computed tomography (HR-pQCT) data from the distal radius of ACPA-positive RA (RA+), ACPA-negative RA (RA-) and healthy controls (HC) micro-finite element analysis (µFEA) was carried out to measure failure load and stiffness of bone.( 1 Comparisons of µFEA parameters between groups was calculated and multivariate models were used to determine the role of demographic, disease-specific and structural data of bone strength. Results: A total of 276 subjects (96 RA+, 84 RA- and 96 HC) were analysed. Age and sex distributions were not significantly different between the three groups. In RA +but not in RA- failure load and stiffness were significantly decreased compared to HC (both p<0.001). Lower bone strength affected both female and male RA +patients and was related to longer disease duration. Impaired bone strength was correlated with altered bone density and microstructural parameters, which were all decreased in RA+. Multivariate models showed that ACPA status (p=0.007) and sex (p<0.001) were independently associated with reduced biomechanical properties of bone in RA. Conclusions: In summary, µFEA showed that bone strength is significantly decreased in RA +but not in RA- disease. Reference: [1] Macneil JA, Boyd SK. Bone strength at the distal radius can be estimated from high-resolution peripheral quantitative computed tomography and the finite element method. Bone2008;42(6):1203–13. Disclosure of Interest: None declared