AB0952 High prevalence of inflammatory and non-inflammatory liver and gastrointestinal diseases in young patients with psoriatic arthritis: a hospital-based study. (12th June 2018) - Batkaeva, N.
Abstract : Background: Psoriatic arthritis (PsA) is associated with numerous comorbidities, including gastrointestinal (GI) and liver diseases (LD). But there is limited data about the prevalence of these disorders among patients (pts) with PsA and severe psoriasis (PsO) in Russian population. Objectives: to evaluate the prevalence of LD and GIT comorbidity in a hospital-based cohort of PsA pts. Methods: 417 (304 Male (M.)/113 Female (F.) PsA pts, according the CASPAR criteria, mean age 38.5±11.3/36.1±11.0 years (yrs) accordingly, PASI 49, 4±0.56, PsA duration 6.6±7.4 years were included. PsA pts with all GIT and LD, including Diseases of oesophagus, stomach and duodenum (K20–K31), Disorders of gallbladder, biliary tract and pancreas (K80–K87), Alcoholic and toxic liver disease (K70–K77) (LD), Viral hepatitis (B15–B19) (VH), non-infectious enteritis and colitis (K55-K63) NEC) were identify in the hospital Database and coding by International Statistical Classification of Disease and Related Health Problems (ICD-10) between 2010–2015 years. M±m, t-test, (%) were calculated. All p<0.05 were considered to indicate statistical significance. Results: 229 (159 – M./70 – F.) out of 417 pts (54.9%) had LD and GIT disorders. Gallbladder, biliary tract and pancreas disease coding as K80–K87 were found in significantly more cases in F. compare to M. pts – in 26 out of 70 pts (37.4%) and in 31 out of 159 pts (19.4%) accordingly (p<0.05). NEC coding as K55-K63 was found in M. only – in 1 out of 159 (0.62%) pts. Diseases of oesophagus, stomach and duodenum coding as K20–K31 were found in 96 out of 229 pts (42%). All of the alcoholic, toxic and viral liver disease were found in 75 out of 229 pts (32.75%). LD coding as K70–K77 were found in 33 out of 75 pts (44%). VH coding as B15–B19 were found in 42 out of 75 pts (56%). No significantly gender differences were found in those group of pts. Conclusions: GIT and LD were found in more than half of young pts with PsA and severe PsO. That information should be taken in account during the choice of safety therapy in this group of pts. Disclosure of Interest: None declared