Illustrative case studies in the return of exome and genome sequencing results. (June 2015)

• Record Type: Journal Article
• Authors: Amendola, Laura M; Lautenbach, Denise; Scollon, Sarah; Bernhardt, Barbara; Biswas, Sawona; East, Kelly; Everett, Jessica; Gilmore, Marian J; Himes, Patricia; Raymond, Victoria M; Wynn, Julia; Hart, Ragan; Jarvik, Gail P
• Is Part Of: Personalized medicine. Volume 12:Number 3(Year 2015)
• Page Start: 283
• Page End: 295
• Publication Date: 2015-06
• Subjects: case studies -- clinical genomics -- exome sequencing -- genetic counseling -- genome sequencing -- genomic medicine -- incidental findings -- personalized medicine -- return of results; Pharmacogenomics -- Periodicals; Pharmacogenetics -- Periodicals; 615.19
• DOI: 10.2217/pme.14.89
• Languages: English
• ISSNs: 1741-0541

Abstract

Whole genome and exome sequencing tests are increasingly being ordered in clinical practice, creating a need for research exploring the return of results from these tests. A goal of the Clinical Sequencing and Exploratory Research (CSER) consortium is to gain experience with this process to develop best practice recommendations for offering exome and genome testing and returning results. Genetic counselors in the CSER consortium have an integral role in the return of results from these genomic sequencing tests and have gained valuable insight. We present seven emerging themes related to return of exome and genome sequencing results accompanied by case descriptions illustrating important lessons learned, counseling challenges specific to these tests and considerations for future research and practice.