Marrow adipogenic lineage precursor: A new cellular component of marrow adipose tissue. Issue 4 (July 2021)

• Record Type: Journal Article
• Authors: Zhong, Leilei; Yao, Lutian; Seale, Patrick; Qin, Ling
• Is Part Of: Best practice & research. Volume 35:Issue 4(2021)
• Publication Date: 2021-07
• Subjects: marrow adipogenic lineage precursor -- single cell RNA-sequencing -- mesenchymal stem cells -- bone remodeling -- hematopoiesis -- angiogenesis; Endocrine glands -- Diseases -- Periodicals; Metabolism -- Disorders -- Periodicals; Endocrinology -- Periodicals; Metabolism -- Periodicals; 616.4
• DOI: 10.1016/j.beem.2021.101518
• Languages: English
• ISSNs: 1521-690X

Abstract

Abstract : Bone marrow mesenchymal stromal cells are a highly heterogenic cell population containing mesenchymal stem cells as well as other cell types. With the advance of single cell transcriptome analysis, several recent reports identified a prominent subpopulation of mesenchymal stromal cells that specifically express adipocyte markers but do not contain lipid droplets. We name this cell type marrow adipogenic lineage precursor, MALP, and consider it as a major cellular component of marrow adipose tissue. Here, we review the discovery of MALPs and summarize their unique features and regulatory roles in bone. We further discuss how these findings advance our understanding of bone remodeling, mesenchymal niche regulation of hematopoiesis, and marrow vasculature maintenance.